| 聂立婷,赵妹,殷秀敏,睢琪玉,王功朝.徒手淋巴引流在乳腺癌术后淋巴水肿中应用效果的Meta分析[J].中国康复,2020,35(5):256-261 |
| 徒手淋巴引流在乳腺癌术后淋巴水肿中应用效果的Meta分析 |
| A meta-analysis on efficacy of manual lymphatic drainage in postoperative lymphedema of breast cancer |
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| DOI： |
| 中文关键词: 徒手淋巴引流 乳腺癌 随机对照试验 Meta分析 |
| 英文关键词: Manual lymph drainage Breast cancer Randomized controlled trial Meta-analysis |
| 基金项目:山东省自然科学基金(ZR2015HM066) |
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| 中文摘要: |
| 目的：评价徒手淋巴引流在乳腺癌患者术后淋巴水肿中的应用效果。方法：计算机检索Cochrane Library、PubMed、Web of Science、EMBASE、中国生物医学文献数据库、中国知网、万方和维普等国内外数据库中有关徒手淋巴引流应用于乳腺癌患者术后淋巴水肿的随机对照试验。经筛选文献，提取资料与评价文献质量后，采用RevMan 5.3软件进行Meta分析。结果：最终纳入11篇随机对照试验, 共2524例患者。Meta分析结果显示，徒手淋巴引流可有效预防乳腺癌患者在术后12个月、6个月、3个月发生淋巴水肿［RR＝0.35，95%CI（0.17，0.74），P<0.01；RR＝0.45，95%CI（0.30，0.68），P<0.01；RR＝0.24，95%CI（0.12，0.48），P<0.01］，可有效减少乳腺癌患者术后淋巴水肿体积 ［WMD＝-52.35，95%CI（-70.51，-34.19），P<0.01］，可有效降低患者术后发生腋窝综合征的风险 ［RR＝0.17，95%CI（0.09，0.34），P<0.01］。结论：徒手淋巴引流能有效预防和治疗乳腺癌患者术后淋巴水肿，以及有效预防腋窝综合征的发生，建议临床推广应用。 |
| 英文摘要: |
| Objective: To evaluate the effectiveness of manual lymph drainage (MLD) in postoperative lymphedema in breast cancer patients. Methods: We searched databases including Cochrane Library, PubMed, Web of Science, EMBASE, CBM, CNKI, Wanfang and VIP. We included all randomized controlled trials (RCTs) that reported the efficacy of MLD in postoperative lymphedema in breast cancer patients. Studies were selected according to inclusion and exclusion criteria, data were extracted, and quality of articles was assessed. Then RevMan 5.3 software was used to analyze the data. Results: A total of 11 RCTs including 2524 patients were incorporated in this meta analysis. The meta analysis showed that MLD could effectively prevent the occurrence of lymphedema after the operation of breast cancer patients at 12th, 6th and 3rd month ［RR=0.24，95%CI (0.16, 0.37), P<0.01; RR=0.45, 95%CI (0.30, 0.68), P<0.01; RR=0.24, 95%CI (0.12, 0.48), P<0.01］, could treat the postoperative lymphedema in breast cancer patients ［WMD=-52.35, 95%CI (-70.51, -34.19)，P<0.01］, and could prevent the occurrence of postoperative axillary syndrome ［RR=0.17, 95%CI (0.09, 0.34), P<0.01］. Conclusion: MLD could effectively prevent and treat the postoperative lymphedema in breast cancer patients, and effectively prevent the occurrence of axillary syndrome. It is suggested to promote clinical application. |
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