| 李昭缘,齐瑞,姜林鸿,赵莉娟,张建忠.低频重复经颅磁刺激对脑卒中后失语症疗效的Meta分析[J].中国康复,2021,36(11):677-683 |
| 低频重复经颅磁刺激对脑卒中后失语症疗效的Meta分析 |
| Efficacy of low-frequency repetitivetranscranial magnetic stimulation for post-stroke aphasia: a meta-analysis |
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| DOI： |
| 中文关键词: 低频重复经颅磁刺激 脑卒中 失语症 Meta分析 |
| 英文关键词: low-frequency repetitive transcranial magnetic stimulation stroke aphasia Meta analysis |
| 基金项目:国家重点研发项目（2018YFC2001600）；上海市卫生健康委中西医结合康复诊疗提升项目（ZY（2018-2020）-FWTX-8002）；上海市卫生计生委加快中医药事业发展三年行动计划项目（ZY（2018-2020）-CCCX-2001-06）；院级基金青年孵育项目（2019YYQ12） |
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| 中文摘要: |
| 目的：通过系统评价研究低频重复经颅磁刺激（low frequency repetitive transcranial magnetic stimulation，LF-rTMS）对脑卒中后失语症（post stroke aphasia，PSA）患者语言功能的干预疗效。方法：计算机检索Pubmed、Embase、Cochrane library、中国知网（CNKI）、万方数据库（WanFang）、维普数据库（VIP）和中国生物医学文献数据库（CBM）中关于rTMS治疗PSA的随机对照试验，文献检索时限限定为从建库至2020年11月。由2名研究员独立按照纳入、排除标准筛选文献，并完成提取数据，核对数据和质量评价等过程，最终采用RevMan 5.3软件进行Meta分析以及相关结果展示。结果：本研究共纳入11篇随机对照试验，共纳入301例PSA患者。试验组干预措施为：常规言语康复训练结合LF-rTMS，对照组干预措施为：常规言语康复训练结合LF-rTMS假刺激。分析结果显示:相较于对照组,经LF-rTMS治疗后，试验组听理解评分（SMD=0.37，95%CI（0.07,0.67），P=0.02）、复述评分（SMD=0.36，95%CI（0.09,0.64），P=0.01）、命名评分（SMD=0.40，95%CI（0.17,0.63），P=0.00007）均显著提高（P<0.05）；试验组与对照组相比具有统计学意义。结论：总结已有相关研究，LF-rTMS治疗对改善PSA患者的语言功能具有明显的效果，对于听理解、复述、命名能力均有显著改善效果。但总体样本量较小，仍需大样本、多中心、以及科学规范化的高质量随机对照试验，进一步完善LF-rTMS治疗PSA患者语言功能的疗效验证。 |
| 英文摘要: |
| Objective: To study the efficacy of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) for the language function of post-stroke aphasia (PSA) patients through the systematic reviews. Methods: The randomized controlled trials (RCTs) of rTMS in the treatment of PSA patients were searched through Pubmed, Embase, Cochrane library, CNKI, WanFang, VIP and CBM from inception to November 2020. Two researchers independently screened the literature according to the inclusion and exclusion criteria, and completed the process of extracting data, checking the data and quality evaluation, and finally RevMan 5.3 software was used to perform a Meta analysis and display related results. Results: A total of 7 RCTs were included in this study, including 152 patients with PSA. The experimental group was given speech therapy combined with LF-rTMS, and the control group was subjected to speech therapy combined with LF-rTMS sham stimulation. The analysis results showed that as compared with the control group, after LF-rTMS treatment, the trial group auditory comprehension score ［SMD=0.37, 95%CI (0.07, 0.67), P=0.02］, repetition score ［SMD=0.36, 95% CI (0.09, 0.64), P=0.01］, naming score ［SMD=0.40, 95%CI (0.17, 0.63), P=0.00007］ were significantly improved in the experimental group (P<0.05). Conclusion: Summarizing existing related studies, LF-rTMS therapy has a significant effect on improving the language function of PSA patients, including auditory comprehension, repetition, naming function, etc，but the sample is still not enough. Therefore, a large sample, multi-center, and scientifically standardized high-quality RCT is still needed to further improve the efficacy verification of LF-rTMS in the treatment of PSA patients’ language function. |
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