文章摘要
宋金辉,丁旭东,黄瓅,洪艳,陈华先,王凤敏,张贵斌.A型肉毒毒素治疗三叉神经痛[J].中国康复,2012,27(1):18-20
A型肉毒毒素治疗三叉神经痛
Botulinum Toxin Type A for the Treatment of Trigeminal Neuralgia
  
DOI:
中文关键词: 三叉神经痛  A型肉毒毒素
英文关键词: trigeminal neuralgia  botulinum toxin type A
基金项目:
作者单位
宋金辉 湖北医药学院附属襄阳医院神经内科湖北 襄阳 441000 
丁旭东 湖北医药学院附属襄阳医院神经内科湖北 襄阳 441000 
黄瓅 湖北医药学院附属襄阳医院神经内科湖北 襄阳 441000 
洪艳 湖北医药学院附属襄阳医院神经内科湖北 襄阳 441000 
陈华先 湖北医药学院附属襄阳医院神经内科湖北 襄阳 441000 
王凤敏 湖北医药学院附属襄阳医院神经内科湖北 襄阳 441000 
张贵斌 湖北医药学院附属襄阳医院神经内科湖北 襄阳 441000 
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中文摘要:
  目的:观察A型肉毒毒素治疗三叉神经痛(TN)的临床疗效。方法:选取57例TN患者,随机分为A、B 2组。A组28例患者口服卡马西平片治疗;B组29例在疼痛部位及板机点周围皮下注射肉毒素治疗。治疗后1,3及6个月时随访,行简式McGill疼痛问卷表(SF-MPQ)及生活质量评价量表(SF-36)评分,并观察不良反应。结果:治疗中脱失7例,A组3例,B组4例。与治疗前3个月SF-MPQ及SF-36平均分作为基础水平比较,治疗1,3及6个月后2组SF-MPQ评分明显下降,SF-36明显上升(P<0.01),B组表明更明显(P<0.05,P<0.01)。治疗过程中,A组出现不适患者多于B组。结论:A型肉毒毒素疼痛点皮下注射治疗TN发作作用高峰1~3个月,维持时间6个月,且临床疗效显著,不良反应轻微。
英文摘要:
  Objective:To observe the clinical efficacy of botulinum toxin type A (BTX-A) for trigeminal neuralgia. Methods:Forty-seven cases of trigeminal neuralgia were randomly divided into two groups, receiving Carbamazeping tabs (control group, A), and subcutaneous injection of BTX-A (therapy group, B), respectively. The onset of trigeminal neuralgia, severity of trigeminal neuralgia, as well as side effects in patients with trigeminal neuralgia were recorded by the use of questionnaire, and compared before and 6 months after treatment. Results:The short form McGill Pain Questionnaire and Quality of Life Scale scores were significantly different before and 1, 3 and 6 months after treatment in both two groups. There was significant difference in the short form McGill Pain Questionnaire and Quality of Life Scale scores between groups A and B 1, 3 and 6 months after treatment (P<0.05). Conclusion: BTX-A has therapeutic effects on trigeminal neuralgia with few side effects.
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