| 尹勇,谷震,杨波,秦冬冬,潘雷,甘露,王廷华,胡新天,冯忠堂.运动再学习对猴脑缺血损伤后脑血流量的影响[J].中国康复,2012,27(2):83-85 |
| 运动再学习对猴脑缺血损伤后脑血流量的影响 |
| Effect of Motor Relearning Program on Regional Cerebral Blood Flow (rCBF) of Rhesus Monkeys with Cerebral Ischemic Stroke |
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| DOI： |
| 中文关键词: 运动再学习疗法 恒河猴 脑缺血 脑血流量 |
| 英文关键词: motor relearning program rhesus monkeys cerebral ischemia regional cerebral blood flow |
| 基金项目:云南省科技厅-昆明医学院联合专项基金资助项目（2008CD37R） |
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| 中文摘要: |
| 目的:观察运动再学习疗法对脑缺血损伤后恒河猴脑血流量的影响。方法:通过电凝法阻断恒河猴右侧大脑中动脉M1段制备成脑缺血损伤模型，术后采用觉醒意识水平肌力训练、协调能力及任务定向训练等运动再学习疗法（MRP），单光子发射计算机体层摄影（SPECT）测定训练前后相关脑区脑血流量的变化。结果：MRP明显改善脑缺血损伤恒河猴的局部脑血流量，但不能改变脑缺血所致的右/左脑区脑血流量的不对称性。结论：MRP可以增加脑缺血损伤周围及相关脑区脑血流量，促进受损神经功能恢复。 |
| 英文摘要: |
| Objective: To observe the effect of motor relearning program (MRP) on regional cerebral blood flow (rCBF) of rhesus monkeys with cerebral ischemic stroke. Methods: Rhesus monkeys subject to an occlusion of the M1 segment of the right middle cerebral artery (MCA) by using electrocoagulation were trained with MRP, and single-photon emission computed tomography (SPECT) was used before and after MCA occlusion to semi-quantify the changes of rCBF. Results: MRP could greatly improve rCBF of the animals with cerebral ischemic stroke, but couldn’t change the functional asymmetry of cerebral hemispheres. Conclusion: It is possible that MRP increases cerebral blood flow in injured areas and other related areas to have a significant improvement on neurological deficits caused by cerebral ischemia. |
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