文章摘要
樊蕴辉,伊红丽,李立群,曹国富,沈海涛.同型半胱氨酸、叶酸及VitB12与血管性痴呆的相关性研究[J].中国康复,2012,27(2):95-96
同型半胱氨酸、叶酸及VitB12与血管性痴呆的相关性研究
Relationship Between Homocysteine, Folate,Vitamin B12 and Vascular Dementia
  
DOI:
中文关键词: 血管性痴呆  同型半胱氨酸  相关性
英文关键词: vascular dementia  homocysteine  relationship
基金项目:
作者单位
樊蕴辉 华北煤炭医学院附属医院神经内科,河北 唐山 063000 
伊红丽 北京天坛医院神经内科,北京 100050 
李立群 华北煤炭医学院附属医院神经内科,河北 唐山 063000 
曹国富 华北煤炭医学院附属医院神经内科,河北 唐山 063000 
沈海涛 华北煤炭医学院附属医院神经内科,河北 唐山 063000 
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中文摘要:
  目的:探讨血浆同型半胱氨酸(Hcy)、叶酸(FA)、VitB12与血管性痴呆(VaD)的相关性。方法:检测VaD患者86例(VaD组),非VaD患者87例(非VaD组),健康体检正常者90例(正常组)血浆Hcy、FA、VitB12浓度。并对3组受检者进行简易智能状态量表(MMSE)评定。结果:VaD组患者Hcy浓度显著高于非VaD组及正常组(P <0.01)。FA、VitB12浓度与Hcy浓度负相关。血浆Hcy、FA、VitB12水平与VaD、MMSE得分显著相关(P <0.01)。结论:VaD高危人群应定期检测Hcy浓度,推荐服用VitB12和FA可预防VaD的发生。
英文摘要:
  Objective: To investigate the relationship between plasma homocysteine (Hcy), folate,vitamin B12 and vascular dementia (VaD). Methods: The plasma levels of Hcy, folate, vitamin B12 and MMSE were measured in 86 VaD patients, 87 non-VaD cerebral vascular disease patients, and 90 age-matched normal controls of Affiliated Hospital, North China Coal Medical University.Results: The plasma Hcy levels were significantly increased in the VaD group than non-VaD cerebral vascular disease group and normal controls (P<0.01). The Hcy level was negatively related with folate and VitB12 levels. They all significantly correlated with VaD and the MMSE score (P<0.01). Conclusion: The levels of Hcy, folate and vitamin B12 were significantly correlated with VaD.
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