| 乐薇,肖颖,黄浩,周利,田佳玉,陈盈芳.电针丰隆穴对高脂血症大鼠巨噬细胞ICAM-1、MCP-1含量的影响[J].中国康复,2013,28(1):3-5 |
| 电针丰隆穴对高脂血症大鼠巨噬细胞ICAM-1、MCP-1含量的影响 |
| Effect of electroacupuncture at "Fenglong" (ST40) on ICAM-1 and MCP-1 in macrophages of rats with hyperlipidemia |
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| DOI： |
| 中文关键词: 电针 丰隆穴 高脂血症 巨噬细胞 胞间粘附分子-1、单核细胞趋化蛋白-1 |
| 英文关键词: electroacupuncture Point ST40 (Fenglong) hyperlipemia macrophages ICAM-1 MCP-1 |
| 基金项目:武汉市卫生局科研项目［武卫(2011)99号］ |
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| 中文摘要: |
| 目的：观察电针丰隆穴对高脂血症大鼠炎症因子细胞间粘附分子(ICAM-1)、单核细胞趋化因子(MCP-1)含量的影响。方法：SD大鼠50只，随机分为空白对照组（A组）、模型对照组（B组）、模型饮控组（C组）、模型电针组（D组）、模型饮控+电针组（E组）各10只。干预60d后，测定血脂含量及ICAM-1、MCP-1的含量。结果：与A组比较，B组大鼠血浆胆固醇(TC)、低密度脂蛋白(LDL-C)含量明显上升（均P<0.01），高密度脂蛋白(HDL-C)明显下降（均P<0.01）；C、D组大鼠血浆TC、LDL-C与B组比较均明显下降（P<0.05,0.01），但较A组均明显升高（均P<0.01）；E组大鼠血浆中TC、LDL-C含量均较B、C组明显降低（均P<0.01）。除E组外，其余各组大鼠腹腔巨噬细胞及ICAM-1、MCP-1含量与A组比较均明显增加（P<0.05,0.01），且B、C组增加更为显著（均P<0.01）；与B、C组比较，E组巨噬细胞及ICAM-1、MCP-1含量显著下降（均P<0.01）。结论：电针丰隆穴能够明显下调高脂血症大鼠血浆中的TC、LDL-C、巨噬细胞及ICAM、MCP-1的含量，从而达到对高脂血症的治疗作用。 |
| 英文摘要: |
| Objective:To study the effect of electroacupuncture at the "Fenglong" on inflammatory factors ICAM-1 and MCP-1 of rats with hyperlipemia (HLP).Methods：Fifty health male SD rats were randomly divided into 5 groups:normal control group (A),model control group (B),model+normal diet group (C),model+electroacupuncture group (D),model+normal diet+electroacupuncture group (E) (n=10 each group).After intervention for 60 days,blood fat and the expression of ICAM-1 and MCP-1 were detected.Results:As compared with group A,the contents of TC and LDL-C were significantly increased and HDL-C significantly reduced in group B(P<0.05,0.01).The contents of TC and LDL-C were significantly decreased in groups C and D as compared with group B,and those in groupsB,C,D were significantly higher than in group A (all P<0.01).As compared with groups B and C,the contents of TC and LDL-C were significantly redeuced in group E(all P<0.01).The number of macrophages,the expression levels of ICAM-1 and MCP-1 in groups B,C,D were obviously increased as compared with group A(P<0.05,0.01),more significantly in groups B and C(all P<0.01).The number of macrophages,and the expression levels of ICAM-1 and MCP-1 in group E were obviously decreased as compared with group B and C(all P<0.01).Conclusion:Electroacupuncture at "Fenglong" can notably decrease the contents of TC and LDL-C,the number of macrophages,and the expression levels of ICAM-1 and MCP-1,thereby have therapeutical effect on hyperlipemia. |
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