| 许秋生,唐强,朱路文.康复预处理对实验性自身免疫性脑脊髓炎小鼠IL-23/IL-17轴的影响[J].中国康复,2013,28(4):286-288 |
| 康复预处理对实验性自身免疫性脑脊髓炎小鼠IL-23/IL-17轴的影响 |
| Effects of rehabilitation pretreatment on IL-23/IL-17 axis of mice with experimental autoimmune encephalomyelitis |
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| DOI： |
| 中文关键词: 实验性自身免疫性脑脊髓炎 康复预处理 IL-23/IL-17轴 |
| 英文关键词: experimental autoimmune encephalomyelitis rehabilitation pretreatment IL-23/IL-17 axis |
| 基金项目:黑龙江省2012年研究生创新科研资金项目（YJSCX2012-346HLJ） |
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| 中文摘要: |
| 目的：探讨康复预处理对实验性自身免疫性脑脊髓炎(EAE)小鼠白介素23(IL-23) /白介素17(IL-17)轴的影响。方法：对C57BL/6小鼠进行为期8周的康复预处理（跑台训练），复制C57BL/6小鼠EAE模型，建立模型组和预处理加模型组（预加模组），并设立空白对照组，观察各组小鼠临床评分，用ELISA法检测各组小鼠血清IL-23和IL-17的表达。结果：预加模组小鼠临床评分明显低于模型组（1.44±0.56、2.75±1.13，P<0.05）。模型组IL-23及IL-17的表达均较空白对照组高（P<0.05），预加模组较模型组低（P<0.05），预加模组和空白对照组比较差异无统计学意义。结论：康复预处理能够延迟EAE发生，这一作用可以通过抑制IL-23/IL-17轴而实现。 |
| 英文摘要: |
| Objective:To explore the effects of rehabilitation pretreatment (RT) on interleukin-23 (IL-23)/IL-17 axis of mice with experimental autoimmune encephalomyelitis (EAE).Methods:After C57BL/6 mice were subjected to rehabilitation pretreatment (treadmill training),EAE model was induced in mice,and EAE group and RT-EAE group were established.Normal mice were selected as control group.The mean neurobehavioral scores were measure,and the serum levels of IL-23 and IL-17 were detected by using ELISA.Results:The mean neurobehavioral scores in RT-EAE group were significantly lower than in EAE group (1.44±0.56 vs. 2.75±1.13,P<0.05).The expression of IL-23 and IL-17 in EAE group was significantly higher than in control group and RT-EAE group (P<0.05).Conclusion:RT can delay the occurrence of EAE probably by inhibiting the IL-23/IL-17 axis. |
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