| 何庆权,张志强,张立新.超早期高压氧对大鼠局灶性脑缺血后梗死体积及脑组织水含量的影响[J].中国康复,2015,30(1):3-6 |
| 超早期高压氧对大鼠局灶性脑缺血后梗死体积及脑组织水含量的影响 |
| Effect of ultra-early hyperbaric oxygen therapy on brain water content and infarction volume after focal cerebral ischemia in rats |
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| DOI： |
| 中文关键词: 大鼠 脑缺血 超早期高压氧 梗死体积 脑组织含水量 |
| 英文关键词: rats cerebral ischemia ultra-early hyperbaric oxygen infarction volume brain water content |
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| 中文摘要: |
| 目的:探讨超早期高压氧(HBO）对大鼠局灶性脑缺血的梗死体积及脑组织含水量的影响。方法:将60只健康的SD大鼠随机分成假手术组、对照组和HBO组各20只，应用线栓法制作大鼠局灶性脑缺血模型，HBO组大鼠给予HBO治疗。各组大鼠均于缺血后12h断头取脑，比较各组脑梗死体积、脑组织水含量。结果:与对照组比较，HBO组梗死体积及脑组织含水量明显减少（P<0.05）。结论:超早期HBO治疗能够减低脑水肿，减小脑梗死体积，进而促进神经功能的恢复、产生治疗作用。 |
| 英文摘要: |
| Objective: To investigate the effect of ultra-early hyperbaric oxygen therapy on focal cerebral ischemia of rats. Method: The thread-occluded method was used to make middle cerebral artery occlusion (MCAO) model. Sixty Sprague-Dawly rats were randomly divided into 3 groups: sham operated group, ischemic control group and hyperbaric oxygen therapy group. The rats were killed 12 h after ischemia. The percentage of infarction (infarct ratio) was calculated by dividing the infarct volume by total volume of the slices. Result: As compared with ischemic control group, the percentage of infarction and brain water content were significantly reduced in hyperbaric oxygen therapy group (P<0.05). Conclusion: Ultra-early hyperbaric oxygen therapy can treat cerebral ischemia effectively via reducing infarction volume and brain water content. |
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