文章摘要
甄晓悦,陆晓.生理性缺血训练对急性脑梗死患者运动功能恢复的影响[J].中国康复,2015,30(4):253-256
生理性缺血训练对急性脑梗死患者运动功能恢复的影响
Effect of physiological ischemic training on motor functional recovery in patients with acute cerebral infarction
  
DOI:
中文关键词: 生理性缺血训练  血管内皮生长因子  脑梗死
英文关键词: physiological ischemic training  vascular endothelial growth factor  cerebral infarction
基金项目:
作者单位
甄晓悦 南京医科大学第一附属医院康复医学科南京 210029 
陆晓 南京医科大学第一附属医院康复医学科南京 210029 
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中文摘要:
  目的:观察等长收缩诱导的生理性缺血训练(PIT)是否能促进急性脑梗死患者功能恢复。方法:将急性脑梗死患者15例随机分为观察组7例和对照组8例,均进行4周的常规康复训练,观察组同时进行4周的PIT。训练前后分别对患者进行Fugl-Meyer、改良Barthel指数(MBI)、健康调查简表(SF-36)评定及血清血管内皮生长因子(VEGF)检测。结果:训练4周后,与训练前比较,2组患者Fugl-Meyer、MBI与SF-36评分均较训练前明显升高(P<0.05),且训练后观察组Fugl-Meyer评分显著高于对照组(P<0.05),MBI和SF-36组间差异均无统计学意义。训练后,观察组患者VEGF明显高于训练前及对照组训练后(P<0.05),对照组血清VEGF训练前后差异无统计学意义。结论:PIT可以促进急性脑梗死患者的运动功能恢复,其可能的机制是通过VEGF的释放增加促进脑缺血区侧支循环生成。
英文摘要:
  Objective: To investigate the effect of physiological ischemia training (PIT) induced by isometric contraction on functional recovery of patients with acute cerebral infarction (ACI). Methods: Fifteen patients with ACI were divided into observation group (n=7) and control group (n=8). All patients received routine rehabilitation training, and those in observation group were given 4-week PIT. Fugl Meyer motor function score, modified Barthel Index (MBI), the MOS 36-item Short Form Health Survey (SF-36) and plasma concentration of vascular endothelial growth factor (VEGF) were measured at baseline and after training. Results: After training for 4 weeks, the Fugl-Meyer, MBI and SF-36 in both two groups were significantly increased as compared with those before training (P<0.05). Fugl-Meyer motor function score in observation group was significantly higher than that in control group (P<0.05), and MBI and SF-36 showed no significant difference between two groups. After training, plasma concentration of VEGF in observation group was significantly higher than before training and in the control group (P<0.05), while that in the control group showed no significant changes. Conclusion: PIT can promote the recovery of motor function in patients with ACI probably by promoting the formation of collateral circulation in remote cerebral ischemia zone by increasing the release of VEGF.
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