| 过婷,袁周玲,武曙燕,吴越.重复经颅磁刺激联合多奈哌齐治疗阿尔茨海默病的临床对照研究[J].中国康复,2016,31(1):54-56 |
| 重复经颅磁刺激联合多奈哌齐治疗阿尔茨海默病的临床对照研究 |
| Control study of repetitive transcranial magnetic stimulation combined with donepezil in treating patients with Alzheimer's disease |
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| DOI： |
| 中文关键词: 重复经颅磁刺激 多奈哌齐 阿尔茨海默病 认知功能 |
| 英文关键词: Repetitive transcranial magnetic stimulation Donepezil Alzheimer's disease Cognitive function |
| 基金项目:无锡市科技发展资金项目 （CSE31N1323） |
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| 摘要点击次数: 11419 |
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| 中文摘要: |
| 目的：探讨重复经颅磁刺激（rTMS）联合多奈哌齐对轻、中度阿尔茨海默病（AD）患者的疗效及安全性。方法： 52例轻、中度AD患者随机分为研究组和对照组各26例，研究组采用rTMS联合多奈哌齐治疗，对照组单用多奈哌齐治疗。2组患者分别在治疗前及治疗4周、8周、12周后进行阿尔茨海默病评定量表认知分量表（ADAS-Cog）、简易精神状态检查量表（MMSE）、日常生活能力量表（ADL）评定，于治疗前及治疗12周后进行事件相关电位P300检测。通过实验室检查和临床观察评定不良反应。结果：治疗4周后，研究组ADAS-Cog、MMSE、ADL评分与治疗前比较差异无统计学意义，治疗8及12周后，研究组ADAS-Cog及ADL评分较治疗前呈持续下降（P＜0.05），MMSE评分较治疗前持续增高（P＜0.05）；对照组治疗4及8周后ADAS-Cog、MMSE、ADL评分与治疗前比较均差异无统计学意义，治疗12周后ADAS-Cog评分、ADL评分较治疗前明显下降（P＜0.05）、MMSE评分较治疗前明显增高（P＜0.05）。组间比较，治疗4周、8周后2组各量表评分差异均无统计学意义，治疗12周后研究组ADAS-Cog评分、ADL评分明显低于对照组（P＜0.05）、MMSE评分明显高于对照组（P＜0.05）。治疗12周后， 2组P300潜伏期均较治疗前明显缩短（P＜0.05）、波幅明显升高（P＜0.05）；组间比较，研究组P300潜伏期明显低于对照组（P＜0.05）、波幅明显高于对照组（P＜0.05）。 结论：rTMS辅助多奈哌齐治疗AD，能有效改善患者的认知功能和日常生活能力，延缓大脑功能衰退，安全性高，且疗效优于单用多奈哌齐。 |
| 英文摘要: |
| Objective:To explore the effect of repetitive transcranial magnetic stimulation (rTMS) combined with donepezil in treating patients with mild or moderate Alzheimer's disease(AD) and its safety. Methods：Five-two patients with mild or moderate AD were randomly divided into the study group (26 cases) and the control group (26 cases). Patients in control group received donepezil treatment alone and those in study group underwent high-rTMS combined with donepezil treatment. The Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), Mini-mental State Examination(MMSE) and Activities of Daily Living (ADL) were performed before and 4 weeks, 8 weeks, 12 weeks after treatment. Event-related potentials (ERP) P300 was performed before and 12 weeks after treatment. Results：As compared with the condition before treatment, the study group at 8th week, 12th week after treatment, the control group at 8th week after treatment, the scores of both ADAS-Cog and ADL were declined significantly, while the MMSE were increased significantly. At 12th week after treatment, P300 latency period of the two groups was reduced significantly, and the amplitude increased significantly. The evaluation indexes in study group were improved better than those in control group. Conclusion：rTMS assisted donepezil could effectively improve the patient's cognitive function and daily living skills, and delay the process of brain function. The combination of rTMS with donepezil is superior to the single use of donepezil with a high safety. |
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