| 徐清,张玉琦,程灶火.高频rTMS对慢性精神分裂症阴性症状的远期康复作用[J].中国康复,2016,31(3):235-237 |
| 高频rTMS对慢性精神分裂症阴性症状的远期康复作用 |
| Long-term efficacy of high-frequency repetitive transcranial magnetic stimulation for treating negative symptoms of chronic schizophrenia |
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| DOI： |
| 中文关键词: 重复经颅磁刺激 精神分裂症 阴性症状 |
| 英文关键词: repetitive transcranial magnetic stimulation schizophrenia negative symptoms |
| 基金项目:无锡市医院管理中心医学科研项目（YGZXQ1307），南京医科大学科技发展面上基金项目（2013NJMU206） |
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| 中文摘要: |
| 目的：探讨高频重复经颅磁刺激（rTMS）对慢性精神分裂症阴性症状的远期康复作用及安全性研究。方法: 慢性精神分裂症患者60例随机分为2组各30例。2组在维持原有抗精神病药物种类及剂量不变的基础上，观察组给予经左侧前额叶背外侧皮质高频rTMS刺激(10Hz)；对照组给予假刺激，刺激部位均选择左侧前额叶背外侧皮质区，刺激强度为80％运动阈值。治疗前、治疗2周后及随访14周后采用阳性与阴性症状量表(PANSS)和阴性症状量表(SANS)量表评定疗效。 结果: 治疗2周后及随访14周时，观察组PANSS总分及阴性因子分、SANS总分均较治疗前及对照组明显降低（均P＜0.01），观察组治疗前后各时间点PANSS阳性因子分及一般精神病理因子分差异无统计学意义；对照组治疗前后各时间点PANSS总分及各因子分、SANS评分差异无统计学意义。结论: 10Hz rTMS模式能改善慢性精神分裂症患者阴性症状，有一定的远期疗效，安全性较好。 |
| 英文摘要: |
| Objective: To investigate the long-term efficacy and safety of high-frequency repetitive transcranial magnetic stimulation (rTMS) for treating the negative symptoms of chronic schizophrenia. Methods: Sixty cases of chronic schizophrenia were randomly assigned to 10 Hz rTMS group (the study group), and sham rTMS group (the control group). In the study group, patients were stimulated with 10 Hz rTMS in the left dorsolateral prefrontal cortex, 5 times every week for 2 weeks. The Positive and Negative Syndrome Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS) were used to assess the improvement of negative symptoms before and 2 weeks after rTMS, and during a follow-up period of 14 weeks. Results: Two weeks after rTMS and during a follow-up period of 14 weeks, the total and the negative symptoms scores of the PANSS and the scores of SANS in the study group were significantly decreased after the treatment (P<0.01) and significantly less than those in the control group (P<0.01). However, the study group had no notable change in positive symptoms and general factors scores of PANSS among different time points. In the control group, the total and each symptom scores of the PANSS and the scores of SANS had no obvious change. Conclusion:10 Hz rTMS has a long-term effectively and safety therapeutic potential on the negative symptoms of chronic schizophrenia. |
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