| 张俊,马将,李红,梅浩男,陶晓琳.重复经颅磁刺激对脑卒中后认知障碍及脂代谢的影响[J].中国康复,2021,36(10):584-588 |
| 重复经颅磁刺激对脑卒中后认知障碍及脂代谢的影响 |
| Effects of repetitive transcranial magnetic stimulation on post-stroke cognitive impairment and lipid metabolism |
| |
| DOI： |
| 中文关键词: 重复经颅磁刺激 脑卒中 认知障碍 甲状腺激素 脂代谢 |
| 英文关键词: repetitive transcranial magnetic stimulation stroke cognitive impairment thyroid hormones lipid metabolism |
| 基金项目:河北省“三三三人才工程”资助项目（A202002023）；河北省科技计划项目（2037727D）；河北省医学科学研究重点课题（20201399） |
|
| 摘要点击次数: 5128 |
| 全文下载次数: 4512 |
| 中文摘要: |
| 目的：观察低频重复经颅磁刺激（rTMS）对脑卒中后认知障碍（PSCI）及脂代谢的影响。方法：43例PSCI患者随机分为rTMS组21例和假刺激组（Sham组）22例。2组患者均给予常规康复治疗及认知功能训练，rTMS组在此基础上给予健侧背外侧前额叶（DLPFC）1Hz、90%运动阈值的rTMS治疗，Sham组给予假刺激，治疗4周。于治疗前、治疗4周后采用简易精神状态量表（MMSE）和蒙特利尔认知量表（MoCA）对患者认知功能进行评估，并检测患者甲状腺激素和血脂水平。结果：治疗后2组患者MMSE评分、MoCA评分较治疗前均显著提高（P＜0.05），且rTMS组患者MMSE评分、MoCA评分均显著高于Sham组（P＜0.05）。rTMS组患者治疗后血清三碘甲状腺原氨酸（T3）、促甲状腺激素水平（TSH）较治疗前显著升高（P＜0.05），总胆固醇（TCHO）水平较治疗前显著下降（P＜0.05）。结论：低频rTMS能改善PSCI患者的认知功能，并且能够升高血清T3、TSH水平，同时降低TCHO水平。 |
| 英文摘要: |
| Objective：To observe the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on post-stroke cognitive impairment (PSCI) and lipid metabolism. Methods: Forty-three PSCI patients were randomly divided into rTMS group (n=21) and Sham rTMS group (n=22). Both groups were given conventional rehabilitation therapy. The rTMS group was given the contralateral dorsolateral prefrontal cortex (DLPFC) 1Hz, 90% motor threshold rTMS treatment, and the Sham group was given false stimulation for 4 weeks. Before and 4 weeks after treatment, the patient’s cognitive function was assessed with the Mini Mental State Scale (MMSE) and Montreal Cognitive Scale (MoCA), and the patient’s thyroid hormone and blood lipid levels were measured. Results: After treatment, the MMSE score and MoCA score in the two groups were significantly higher than those before treatment (P<0.05), and the MMSE score and MoCA score in the rTMS group were significantly higher than those in the Sham group (P<0.05). After treatment in the rTMS group, serum triiodothyronine (T3) and thyroid-stimulating hormone (TSH) levels were significantly higher than those before treatment (P<0.05); total cholesterol (TCHO) levels were significantly lower than those before treatment (P<0.05). Conclusion: Low-frequency rTMS can improve the cognitive function of PSCI patients, and can increase serum T3 and TSH levels, while reducing TCHO levels. |
|
查看全文
下载PDF阅读器 HTML全文 |
| 关闭 |
