| 石雅馨,卢世玲,王瑜,许婷.高压氧在不同程度肺功能异常尘肺患者中的应用研究[J].中国康复,2022,37(4):228-231 |
| 高压氧在不同程度肺功能异常尘肺患者中的应用研究 |
| Application of hyperbaric oxygen in pneumoconiosis patients with different degrees of abnormal pulmonary function |
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| DOI： |
| 中文关键词: 尘肺 肺功能 高压氧 血气分析 |
| 英文关键词: Pneumoconiosis Lung function Hyperbaric oxygen Blood gas analysis |
| 基金项目:广西壮族自治区卫生和计划生育委员会自筹经费科研课题（Z2015025） |
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| 中文摘要: |
| 目的：观察高压氧在不同程度肺功能异常尘肺患者中的应用效果。方法：选取160例尘肺患者作为研究对象，采用随机数表法分为观察组和对照组各80例，对照组患者均进行常规治疗，观察组患者在对照组常规治疗基础上联合高压氧治疗，2组均连续治疗20d。比较2组不同程度肺功能异常患者治疗前、治疗20d后Borg量表评分、第1秒用力呼气容积（FEV1）、FEV1/用力肺活量（FVC）、每分钟最大通气量（MVV）、动脉血氧饱和度（SpO2）、动脉血氧分压（PaO2）以及动脉二氧化碳分压（PaCO2）的变化。结果：治疗20d后，2组不同程度肺功能异常患者治疗后Borg量表评分均明显低于治疗前（均P＜0.05），观察组中的轻度组、中度组、重度组患者Borg量表评分分别低于对照组中的轻度组、中度组、重度组患者（均P＜0.05）；治疗后，2组不同程度肺功能异常患者治疗后FEV1、FEV1/FVC、MVV均明显高于治疗前（均P＜0.05），观察组中的轻度组、中度组、重度组患者FEV1、FEV1/FVC、MVV均分别高于对照组的轻度组、中度组、重度组患者（均P＜0.05）；治疗后，2组不同程度肺功能异常患者治疗后SpO2、PaO2均明显高于治疗前（均P＜0.05），PaCO2明显低于治疗前（均P＜0.05），观察组中的轻度组、中度组、重度组患者SpO2、PaO2均分别高于对照组中的轻度组、中度组、重度组患者（均P＜0.05），PaCO2分别低于对照组的轻度组、中度组、重度组患者（均P＜0.05）。结论：高压氧在不同程度肺功能异常尘肺患者中均具有明显的治疗效果，值得临床推广。 |
| 英文摘要: |
| Objective: To study the application of hyperbaric oxygen in pneumoconiosis patients with different degrees of abnormal pulmonary function. Methods: A total of 160 cases of pneumoconiosis admitted to Guangxi Institute of Occupational Disease Prevention and Control from January 2019 to March 2021 were selected. According to the method of random number table, the patients were divided into the observation group and the control group, with 80 cases in each group. The patients in the control group received conventional treatment, and those in the observation group were treated with hyperbaric oxygen on the basis of the control group. Both groups were treated for 20 days. The changes in Borg scale scores, forced expiratory volume in the first second (FEV1), FEV1/forced vital capacity (FVC), and maximum ventilation per minute ( MVV), arterial blood oxygen saturation (SPO2), arterial blood oxygen partial pressure (PaO2) and arterial carbon dioxide partial pressure (PaCO2) were compared before and 20 days after treatment in two groups with different degrees of abnormal pulmonary function. Results: After 20 days of treatment, the Borg scale scores of patients with different degrees of pulmonary dysfunction in the two groups were significantly lower than those before treatment. The Borg scale scores of the patients in the mild, moderate, and severe subgroups in the observation group were significantly lower than those in the mild, moderate, and severe subgroups in the control group with the difference being statistically significant (P<0.05) After treatment, the FEV1, FEV1/FVC and MVV of patients with different degrees of pulmonary dysfunction in the two groups were significantly higher than those before treatment, and those of patients in the mild, moderate, and severe subgroups in the observation group were significantly higher than those in the mild, moderate, and severe subgroups in the control group with the difference being statistically significant (P<0.05). After treatment, the SPO2 and PaO2 of patients with different degrees of pulmonary dysfunction in the two groups were significantly higher than those before treatment, and PaCO2 was significantly lower than that before treatment. The SPO2 and PaO2 of patients in the mild, moderate, and severe subgroups in the observation group were significantly higher, and PaCO2 was significantly lower than those in the mild, moderate, and severe subgroups in the control group with the difference being statistically significant (P<0.05). Conclusi-on: Hyperbaric oxygen has obvious effectiveness in patients with pneumoconiosis with different degree of abnormal lung function, which is worthy of clinical promotion. |
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