| 艾伟平,郭占芳,张晓杰,张靖.抗阻力训练联合计算机化认知训练治疗脑卒中后轻度认知障碍的疗效分析[J].中国康复,2022,37(8):456-459 |
| 抗阻力训练联合计算机化认知训练治疗脑卒中后轻度认知障碍的疗效分析 |
| Efficacy of anti-resistance training combined with computerized cognitive training for mild cognitive impairment after stroke |
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| DOI： |
| 中文关键词: 抗阻力训练 计算机化认知训练 脑卒中 认知障碍 |
| 英文关键词: Resistance training Computerized cognitive training Stroke Cognitive impairment |
| 基金项目:张家口市重点研发计划项目（2121185D） |
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| 中文摘要: |
| 目的：探讨抗阻力训练联合计算机化认知训练（CCT）治疗脑卒中后轻度认知障碍的疗效。方法：116例脑卒中后轻度认知障碍患者，随机分为2组各58例。对照组采用CCT训练，观察组采用抗阻力训练联合CCT训练。比较2组认知功能、注意和执行功能、记忆功能、生活能力、血清脑源性神经营养因子（BDNF）、神经元特异性烯醇化酶（NSE）、C反应蛋白（CRP）、白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）的差异。结果：训练8周后，2组MMSE评分、MoCA评分、RBMT评分、BI指数、血清BDNF、NSE水平均较训练前增高（均P＜0.05），且观察组高于对照组（P＜0.05）；2组完成数字卡片排序时间均较训练前缩短（均P＜0.05），且观察组低于对照组（P＜0.05）；2组血清CRP、IL-6、IL-1β水平均较训练前降低（均P＜0.05），且观察组低于对照组（P＜0.05）。结论：抗阻力训练联合CCT治疗可更有效地降低脑卒中后轻度认知障碍患者血清炎症因子水平，增加血清神经因子水平，改善认知、注意和执行、记忆功能，提高生活能力。 |
| 英文摘要: |
| Objective: To investigate the efficacy of resistance training combined with computerized cognitive training (CCT) for mild cognitive impairment (MCI) after stroke. Methods: A total of 116 patients with post-stroke mild cognitive impairment admitted to the First Hospital of Zhangjiakou city from August 2018 to August 2021 were selected. The patients were divided into control group and observation group by random number table method, with 58 cases in each group. The control group received CCT training for 8 weeks, and the observation group received resistance training combined with CCT training for 8 weeks. The differences in cognitive function, attention and executive function, memory function, living ability, serum brain-derived neurotrophic factor (BDNF), neuron specific enolase (NSE), C-reactive protein (CRP), interleukin-6 (IL-6) and IL-10 were compared between the two groups. Results: After training, MMSE score, MoCA score, RBMT score, BI index, serum BDNF and NSE levels were higher than before training (P<0.05), and the time to complete the sorting of digital cards was shorter than before training (P<0.05). Serum CRP, IL-6 and IL-1β levels were lower than those before training (P<0.05). MMSE score, MoCA score and RBMT score, BI index, serum BDNF, NSE in the observation group after training was significantly higher than those in the control group (P<0.05). The sorting time of digital cards, serum CRP, IL-6 and IL-1β in the observation group were lower than those in the control group (P<0.05). Conclusion: Anti-resistance training combined with CCT can effectively reduce the level of serum inflammatory factors and increase the level of serum neurofactors in patients with mild cognitive impairment after stroke, improve the cognitive, attention, executive and memory functions, and improve life ability. |
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