| 梅娜,李惠芬.镜像结合动作观察疗法对脑卒中患者上肢功能及tau蛋白、GDNF表达的影响[J].中国康复,2022,37(11):643-647 |
| 镜像结合动作观察疗法对脑卒中患者上肢功能及tau蛋白、GDNF表达的影响 |
| Effects of mirror therapy combined with action observation therapy on upper limb function and expression of serum tau protein and GDNF in patients with stroke hemiplegia |
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| DOI： |
| 中文关键词: 镜像疗法 动作观察疗法 卒中 偏瘫 上肢功能 |
| 英文关键词: mirror therapy action observation therapy stroke hemiplegia upper limb function |
| 基金项目:苏州市科技发展计划项目（SYS201786） |
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| 中文摘要: |
| 目的：探讨镜像结合动作观察疗法对脑卒中偏瘫患者上肢功能及血清tau蛋白、胶质细胞源性神经营养因子（GDNF）表达的影响。方法：脑卒中偏瘫患者135例，随机分成研究组、对照1组、对照2组，每组均45例。研究过程中每组均有2例脱落。3组患者均接受康复治疗，在此基础上，研究组采取镜像结合动作观察疗法，对照1组采取镜像疗法，对照2组实施动作观察疗法。比较3组神经功能恢复情况、上肢功能、日常生活活动能力的变化及血清tau蛋白、GDNF表达水平。结果：治疗4周后，3组临床神经功能缺损程度量表（CNDS）评分与治疗前相比均降低（P＜0.05），且研究组CNDS评分较对照1、2组低（P＜0.05）；3组Fugl-Meyer运动功能评分法（FMA）中上肢功能评分、Barthel指数评定量表（BI）评分与治疗前相比均增高（P＜0.05），且研究组上肢功能评分、BI评分均较对照1、2组高（P＜0.05）；3组血清tau蛋白表达水平与治疗前相比均降低（P＜0.05），血清GDNF表达水平与治疗前相比均升高（P＜0.05），且研究组血清tau蛋白水平较对照1、2组低（P＜0.05），血清GDNF水平较对照1、2组高（P＜0.05）。结论：对卒中偏瘫患者实施镜像结合动作观察疗法，可显著降低患者神经功能缺损程度，明显改善患者上肢功能及日常生活活动能力，且能有效调节血清tau蛋白、GDNF的表达。 |
| 英文摘要: |
| Objective: To explore the effects of mirror therapy combined with action observation therapy on upper limb function and expressions of serum tau protein and glial cell line-derived neurotrophic factor (GDNF) in stroke hemiplegic patients. Methods: A total of 135 patients with hemiplegia after stroke were divided into control group 1, control group 2 and study group according to the random number table method. During the study period, 2 cases fell off in each group, and 43 cases were included in each group. All patients received rehabilitation treatment. On this basis, the control group 1 received mirror therapy, the control group 2 received action observation therapy, and the study group received mirror therapy combined with action observation therapy. Neurological function recovery, upper limb function, activities of daily living, serum Tau protein and GDNF expression levels were compared among the three groups. Results: After treatment, the scores of CNDS in the three groups were lower than those before treatment (P<0.05), and the CNDS score in the study group was lower than that in the control groups 1 and 2 (P<0.05). The upper extremity function score in Fugl Meyer motor function score (FMA) and Barthel index (BI) score after treatment in the three groups were higher than those before treatment (P<0.05), and the upper limb function score and BI score in study group were higher than those in control groups 1 and 2 (P<0.05). The expression level of serum tau protein after treatment in the three groups was lower than that before treatment (P<0.05), and that of serum Tau protein was lower (P<0.05) and the serum GDNF level was higher (P<0.05) after treat-ment in the study group than in control groups 1 and 2. Conclusion: The mirror therapy combined with action observation therapy can significantly reduce the degree of neurological deficit, improve the upper limb function and the ability of daily life, and effectively regulate the expression of serum tau protein and GDNF. |
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