| 赵彬,张金朋,李宏玉,杨可钦,唐强.针康法对脑卒中后抑郁患者血清脑源性神经营养因子、血管内皮生长因子及抑郁状态的影响[J].中国康复,2022,37(12):713-717 |
| 针康法对脑卒中后抑郁患者血清脑源性神经营养因子、血管内皮生长因子及抑郁状态的影响 |
| Effects of acupuncture and health therapy on endogenous factors of brain-derived neurotrophic factor, vascular endothelial growth factor and depressive state in patients with post-stroke depression |
| |
| DOI： |
| 中文关键词: 针康法 脑卒中后抑郁 脑源性神经营养因子 血管内皮生长因子 抑郁 |
| 英文关键词: Acupuncture therapy Post-stroke depression Brain-derived neurotrophic factor Vascular endothelial growth factor Depression |
| 基金项目:黑龙江省自然基金重点项目（ZD2019H007）；黑龙江中医药大学校基金项目(201506) ；黑龙江中医药大学附属第二医院院基金项目（YM-201707）；黑龙江省第二批省级中医临床优秀人才计划(No. 202228)；黑龙江博士后资助项目（No.LBH-Z22290） |
|
| 摘要点击次数: 1711 |
| 全文下载次数: 4358 |
| 中文摘要: |
| 目的：探讨针康法对脑卒中后抑郁（PSD）患者血清脑源性神经营养因子（BDNF）、血管内皮生长因子（VEGF）水平及抑郁状态的影响。方法：40例脑卒中后抑郁患者随机分为常规康复组（对照组）和针康组（观察组），每组20例，对照组在康复科常规康复治疗基础上给予心理康复治疗，观察组在对照组基础上进行头穴丛刺治疗（针康法）。比较2组患者治疗4周后汉密尔顿抑郁量表（HAMD）、Fugl-Meyel运动功能评估量表、改良Barthel指数量表（MBI）评分，检测血清脑源性神经营养因子（BDNF）、血管内皮生长因子（VEGF）水平差异，HAMD与BDNF、VEGF相关性分析。结果：治疗前2组患者HAMD评分、Fugl-Meyel及MBI评分、BDNF及VEGF水平比较差异无统计学意义。治疗4周后，2组HAMD评分较治疗前均有下降(P＜0.01)，且观察组低于对照组(P＜0.01)；2组Fugl-Meyel及MBI评分、BDNF及VEGF水平较治疗前均有明显上升(P＜0.05)，且观察组均高于对照组 (P＜0.05)。HAMD评分与BDNF呈负相关（r=-0.571，P=0.000）；HAMD评分与VEGF呈负相关（r=-0.551，P=0.000）。结论：针康法可明显改善PSD患者抑郁状态，提高患者运动功能及日常生活功能。其抑郁状态好转作用机制可能与提高血清BDNF、VEGF水平有关。 |
| 英文摘要: |
| Objective: To investigate the effect of acupuncture and health therapy on serum levels of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), and depressive states in patients with post-stroke depression (PSD). Methods: A total of 40 patients with PSD from January 2019 to December 2021 in the rehabilitation inpatient ward and outpatient department of the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine were selected and divided into a conventional rehabilitation group (control group) and acupuncture-rehabilitation group (observation group) according to the random number table method (20 cases in each group). The control group was given psychological rehabilitation treatment on the basis of routine rehabilitation treatment in the rehabilitation department, and the observation group was given scalp acupuncture treatment (acupuncture and health method) on the basis of the control group. The Hamilton Depression Scale (HAMD), Fugl-Meyel Motor Function Assessment Scale, Modified Barthel Index (MBI) score, serum markers BDNF and VEGF levels were compared between the two groups after 4 weeks of treatment. Results: Before treatment, there was no significant difference in HAMD scores, Fugl-Meyel scores and MBI, serum levels of BDNF and VEGF between two groups. After treatment of 4 weeks, the HAMD scores in two groups were significantly reduced as compared with those before treatment (P<0.01), and those in observation group were lower than those in the control group (P<0.01); The Full-Meyel scores and MBI, serum levels of BDNF and VEGF in two groups were significantly increased as compared with those before treatment (P<0.05), and those in observation group were significantly higher than those in the control group (P<0.05). HAMD scores were negatively correlated with BD-NF (r=-0.571, P=0.000) and VEGF (r=-0.551, P=0.000). Conclusion： Acupuncture can improve the depression of PSD patients, and improve the patient's motor function and daily life function, which may be related to the increase in serum BDNF and VEGF levels. |
|
查看全文
下载PDF阅读器 HTML全文 |
| 关闭 |
|
|
|
