文章摘要
李思静,席艳玲.基于动态局部一致性的脑卒中后运动性失语症患者语言网络特征的研究[J].中国康复,2024,39(9):515-520
基于动态局部一致性的脑卒中后运动性失语症患者语言网络特征的研究
Characterization of language networks in patients with post-stroke Broca aphasia based on dynamic regional homogeneity
  
DOI:10.3870/zgkf.2024.09.001
中文关键词: 动态局部一致性  Broca失语  静息态功能磁共振成像
英文关键词: dynamic regional homogeneity  Broca aphasia  resting state-functional magnetic resonance imaging
基金项目:上海市浦东新区科技发展基金事业单位民生科研专项项目(PKJ2022-Y30);中央财政支持中医药传承创新发展示范试点项目-中医康复高原学科(YC-2023-0606)
作者单位
李思静 新疆医科大学第一附属医院康复医学科乌鲁木齐 830000 
席艳玲 1.新疆医科大学第一附属医院康复医学科乌鲁木齐 8300002.上海市浦东新区光明中医医院康复科上海 200120 
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中文摘要:
  目的:基于静息态功能磁共振成像技术(rs-fMRI)研究脑卒中后Broca失语(BA)的语言网络的动态局部一致性(dReHo)变化的特征。方法:选取维、汉语BA患者21例,以及与其性别、年龄、教育程度相匹配的健康者28例。将健康者28例随机分为维语健康组13例和汉语健康组15例;将BA患者21例随机分为维语患者组9例和汉语患者组12例。4组完成语言行为学评定后进行静息态功能磁共振扫描,对影像数据预处理后进行动态局部一致性的计算,使用双因素协方差分析,获取失语与语种存在交互作用的脑区,并对维、汉语BA患者dReHo的时间变异性异常的脑区与语言行为学之间进行偏相关分析。结果:4组研究对象在左侧眶部额下回、左侧海马和左侧缘上回dReHo的时间变异性存在交互作用。维语患者组左侧眶部额下回dReHo的时间变异性高于维语健康组和汉语患者组(P<0.05),左侧海马dReHo的时间变异性低于维语健康组和汉语患者组(P<0.05);汉语患者组左侧眶部额下回dReHo的时间变异性低于汉语健康组和维语患者组(P<0.05),左侧海马dReHo的时间变异性高于汉语健康组和维语患者组(P<0.05),左侧缘上回dReHo的时间变异性低于汉语健康组和维语患者组(P<0.05)。维、汉语患者组dReHo的时间变异性异常的脑区与语言行为学的相关性:维语患者组在左侧眶部额下回的dReHo的时间变异性与词命名、姓名地址呈正相关(P<0.05);汉语BA患者在左侧海马的dReHo的时间变异性与听写呈正相关(P<0.05)。结论:静息态下维、汉语BA患者语言功能脑区的dReHo的变化存在差异。其中,左侧眶部额下回dReHo的时间变异性增强可能在维语BA患者的语音加工过程发挥代偿作用;而左侧海马dReHo的时间变异性增强可能与汉语BA患者语言功能重组有关。
英文摘要:
  Objective: To study characterization of dynamic regional homogeneity (dReHo) changes in the language network of Broca aphasia (BA) after stroke based on resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Totally, 21 cases of Wei and Chinese BA patients as well as 28 cases of healthy people matched with their gender, age, and education level, were selected. The 49 study subjects were divided into 4 groups: control group (a healthy group of Uygur and a healthy group of Chinese speakers); observation group (a group of Uygur speakers patients and a group of Chinese speakers patients). The 4 groups were given resting-state functional magnetic resonance scans after the linguistic behavioural assessment. dReHo was calculated after pre-processing the image data. The two-factor analysis of covariance was used to obtain the brain regions where there was an interaction between aphasia and language, and a bias correlation analysis was performed between brain areas with abnormal temporal variability in dReHo and language behavioural in patients with Uygur and Chinese BA. Results: There was an interaction among the four study groups for temporal variability of dReHo in the left inferior orbital frontal gyrus, the left hippocampus and the left supramarginal gyrus. The temporal variability of dReHo in the left inferior orbital frontal gyrus was higher in the Uygur patient group than in the Uygur healthy group and the Chinese patient group (P<0.05), that in the left hippocampus was lower in the Uygur patient group than in the Uygur healthy group and the Chinese patient group (P<0.05), that in the left inferior orbital gyrus was lower in the Chinese patient group than in the Chinese healthy group and the Uygur patient group (P<0.05), that in the left hippocampus in the Chinese patient group was higher than that in the Chinese healthy group and the Uygur patient group (P<0.05), and that in the left supramarginal gyrus was lower in the Chinese patient group than that of the Chinese healthy group and the Uygur patient group (P<0.05). The temporal variability of dReHo in the left inferior orbital frontal gyrus was positively correlated with word naming (P<0.05) and name address (P<0.05) in the Uygur patient group. The temporal variability of dReHo in the left hippocampus was positively correlated with dictation (P<0.05) in the Chinese-speaking BA patients. Conclusion: Differences exist in the changes of dReHo in the functional brain regions of language in resting state in Uygur and Chinese BA patients. Among them, the enhanced temporal variability of dReHo in the left inferior orbital frontal gyrus may play a compensatory role in the phonological processing of Uygur BA patients, while the enhanced temporal variability of dReHo in the left hippocampus may be related to the recovery of language function in Chinese BA patients.
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