| 陈秋宇,王世雁,巩尊科,林子芊,王翔,陈晓宇.间歇性Theta爆发式刺激联合正中神经电刺激对卒中后认知障碍的影响[J].中国康复,2025,40(6):332-337 |
| 间歇性Theta爆发式刺激联合正中神经电刺激对卒中后认知障碍的影响 |
| Effect of iTBS combined with median nerve electrical stimulation on post-stroke cognitive impairment |
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| DOI：10.3870/zgkf.2025.06.002 |
| 中文关键词: 卒中后认知障碍 间歇性θ爆发式刺激 正中神经电刺激 脑电图 功率谱密度 蒙特利尔认知评估量表 洛文斯顿认知评定量表 |
| 英文关键词: post-stroke cognitive impairment intermittent Theta burst stimulation median nerve electrical stimulation electroencephalogram power spectral density Montreal cognitive assessment Loewenstein occupational therapy cognitive assessment |
| 基金项目:徐州市科技局重点研发计划（社会发展）-医药卫生面上项目（KC23190） |
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| 中文摘要: |
| 目的：探讨间歇性Theta爆发式刺激（iTBS）联合正中神经电刺激（MNS）对卒中后认知障碍（PSCI）患者认知功能的影响。方法：选取45位PSCI患者为研究对象，采用随机数字表法分为联合组、iTBS组、对照组，每组15例。3组患者均接受常规康复治疗，在此基础上联合组接受MNS与iTBS治疗、iTBS组接受iTBS治疗。iTBS、MNS与常规康复治疗均为每日1次，每周5次，共治疗4周。在治疗前后分别采用蒙特利尔认知评估量表（MoCA）、洛文斯顿作业疗法认识评定量表（LOTCA）及定量脑电图［包括功率谱密度（PSD）及慢波化比率（DTABR）］比较3组患者的认知功能治疗的效果。结果：治疗后3组患者MoCA、LOTCA量表评分均较治疗前明显提高（P<0.05），相较于对照组与iTBS组，联合组MoCA评分LOTCA评分均显著提高（P<0.05），PSD、DTABR评分均较治疗前有显著改善（P<0.05），且联合组最优。结论：iTBS与MNS联合治疗对PSCI患者认知功能恢复的治疗效果，较单一iTBS治疗更有优势。 |
| 英文摘要: |
| Objective: To investigate the influences of intermittent Theta burst stimulation (iTBS) in combination with median nerve electrical stimulation (MNS) on the cognitive function of patients with post-stroke cognitive impairment (PSCI). Methods: Totally, 45 patients with PSCI were chosen as the research subjects and were categorized into the combined treatment group, the iTBS group, and the control group via the random number table method, with 15 cases in each group. All the patients in the three groups received conventional rehabilitation therapy. Based on this, the combined treatment group received both MNS and iTBS treatment, the iTBS group received only iTBS treatment, and the control group received conventional rehabilitation treatment. iTBS, MNS, and conventional rehabilitation treatment were all provided once a day, 5 times a week, for a total duration of 4 weeks. Before and after the treatment, the Montreal Cognitive Assessment Scale (MoCA), the Loewenstein Occupational Therapy Cognitive Assessment Scale (LOTCA), and quantitative electroencephalogram ［including power spectral density (PSD) and slow wave ratio (DTABR)］ were employed to compare the therapeutic effects of cognitive function among the three groups. Results: After the treatment, all three groups exhibited improvement on the scores of the MoCA and LOTCA compared to before（P<0.05）. Compared with the control group and iTBS group, Moca and LOCTA in the combination group were significantly inscreased (P<0.05). After treatment, The PSD and DTABR combined group and iTBS groups were improved significantly (P<0.05), and the combined group was optimal（P<0.05）. Conclusion: The therapeutic effect of iTBS combined with MBS on the cogni-tive function recovery in PSCI patients is better than the single iTBS treatment. |
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