| 王琼瑶,夏文广,种玉飞,龚婧仪,吴青青,黎明.基于功能成像技术探讨针刺治疗轻度认知障碍机制的研究进展[J].中国康复,2025,40(11):678-682 |
| 基于功能成像技术探讨针刺治疗轻度认知障碍机制的研究进展 |
| Research progress in the mechanism of acupuncture treatment for mild cognitive impairment based on functional Imaging techniques |
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| DOI：10.3870/zgkf.2025.11.007 |
| 中文关键词: 针刺 轻度认知功能障碍 功能成像技术；研究进展 |
| 英文关键词: acupuncture mild cognitive impairment functional imaging techniques research progress |
| 基金项目:湖北省中医药管理局项目（ZY2023M016）；湖北省科技厅揭榜制项目（KJJB2023000058）；湖北省卫生健康委员会项目（WJ2023M101） |
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| 中文摘要: |
| 轻度认知功能障碍（MCI）是一种多因素、复杂的中枢神经系统退行性疾病，目前缺乏有效药物，针刺治疗显示出良好干预潜力。本文综述基于fMRI和fNIRS技术的研究表明，针刺可通过调节前额叶、扣带皮层、海马等脑区的神经活动，增强默认模式网络（DMN）、中央执行网络（CEN）和突出网络(SN)等重要脑网络的功能连接，改善脑血流与认知功能。现有研究多集中于验证疗效，机制探讨仍显不足，且评估方法较为单一。未来应整合多模态功能成像技术，深入揭示针刺治疗MCI的神经机制，为临床推广应用提供更充分的科学依据。 |
| 英文摘要: |
| Mild cognitive impairment (MCI) is a multifactorial and complex neurodegenerative disorder for which effective pharmacological treatments are currently lacking. In this context, acupuncture has emerged as a promising therapeutic intervention. This review synthesizes evidence from studies utilizing functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS), indicating that acupuncture can modulate neural activity in brain regions such as the prefrontal cortex, cingulate cortex, and hippocampus. It further enhances functional connectivity within critical brain networks, including the default mode network (DMN), central executive network (CEN), and salience network (SN), thereby improving cerebral hemodynamics and cognitive performance. Current research remains predominantly focused on efficacy validation, with mechanistic investigations still insufficient and methodologies relatively limited. Future studies should prioritize the integration of multimodal functional imaging techniques to systematically elucidate the neurobiological mechanisms underlying acupuncture treatment for MCI, thereby providing a more robust scientific foundation for its clinical translation and broader application. |
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