| 梅子涵,周仕媛,王梦寰,林枫,江钟立.深呼吸与迷走神经电刺激对大脑皮层静息态低频振幅分数影响的比较[J].中国康复,2026,41(1):8-14 |
| 深呼吸与迷走神经电刺激对大脑皮层静息态低频振幅分数影响的比较 |
| Comparison of the effects of deep breathing and vagus nerve stimulation on cortical fractional amplitude of low frequency fluctuations |
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| DOI：10.3870/zgkf.2026.01.002 |
| 中文关键词: 深呼吸训练 低碳酸血症 低频振幅分数 功能近红外光谱 迷走神经刺激 |
| 英文关键词: Deep breathing training Hypocapnia Fractional amplitude of low-frequency fluctuation Functional near-infrared spectroscopy Vagus nerve stimulation |
| 基金项目:南京医科大学科技发展基金（NMUB2018295） |
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| 中文摘要: |
| 目的：比较深呼吸与经皮耳迷走神经电刺激（taVNS）对大脑皮层静息态皮层低频振幅分数（fALFF）影响的差异及其潜在机制。方法：30名健康受试者随机分为深呼吸组和taVNS组。深呼吸组先实施深呼吸干预，随后接受taVNS干预；taVNS组先实施taVNS干预，再进行深呼吸干预。2项干预的持续时间均为20min，洗脱期为48h。每次干预开始前及结束后立即测量5min心率变异性（HRV）与静息态功能性近红外光谱技术（fNIRS），干预过程中持续监测呼气末二氧化碳分压（PetCO2）。结果：深呼吸组PetCO2显著下降（P<0.01），N-N 间期的标准差（SDNN）显著增加（P<0.05），前额叶（PFC）和感觉运动皮层（SMC）的低频振幅分数（fALFF）均显著下降（P<0.01）。在15min、20min时间点PetCO2与fALFF呈显著正相关（P<0.01）。taVNS组连续 NN 间期均方差的平方根（RMSSD）显著增加（P<0.01）、低频/高频功率比值（LF/HF）显著下降（P<0.05），脑区fALFF及PetCO2无显著变化。结论：CO2介导的血管效应是深呼吸引起皮层低频振幅分数（fALFF）下降的主要机制，而即时taVNS对皮层fALFF无显著调节作用。 |
| 英文摘要: |
| Objective: To study the different effects of deep breathing and transcutaneous auricular vagus nerve stimulation (taVNS) on the fractional amplitude of low-frequency fluctuations (fALFF) in the resting-state cortex and their underlying mechanisms. Methods:In this randomized crossover design study, 30 healthy volunteers completed a single 20-minute session of deep breathing training and a single 20-minute session of taVNS, with the order of interventions randomized. The two sessions were separated by a washout period of at least 48 h. Measurements of 5-min heart rate variability (HRV) and resting-state functional near-infrared spectroscopy (fNIRS) were obtained immediately before and after each intervention. End-tidal carbon dioxide (PetCO2) was continuously monitored throughout the intervention process. Results:The deep breathing group exhibited significantly decreased PetCO2 (P<0.01), increased standard deviation of NN intervals (SDNN)(P<0.05), and reduced fALFF in both prefrontal cortex (PFC) and sensorimotor cortex (SMC) (P<0.01). A significant positive correlation emerged between PetCO2 and fALFF at 15 min、20min (P<0.01). Conversely, the taVNS group demonstrated increased root mean square of successive RR interval differences (RMSSD）（P<0.01) and decreased low-frequency/high-frequency power ratio (LF/HF）（P<0.05), but no significant alterations in cerebral fALFF or PetCO2.Conclusion: The primary mechanism by which deep breathing induces a decrease in the fALFF in the cortex is mediated through CO2-induced vascular effects, whereas taVNS does not significantly modulate cortical fALFF. |
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