| 李影,孙丽,程羽萱,王艳娟.体外膈肌起搏联合分阶段康复训练对慢阻肺急性加重期机械通气患者的疗效观察[J].中国康复,2026,41(1):27-30 |
| 体外膈肌起搏联合分阶段康复训练对慢阻肺急性加重期机械通气患者的疗效观察 |
| Influence of external diaphragm pacing combined with staged rehabilitation training on the therapeutic effect of mechanical ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease |
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| DOI：10.3870/zgkf.2026.01.005 |
| 中文关键词: 慢性阻塞性肺疾病 急性加重期 体外膈肌起搏 康复训练 血气分析 |
| 英文关键词: chronic obstructive pulmonary disease acute exacerbation period extracorporeal diaphragmatic pacing rehabilitation training blood gas analysis |
| 基金项目:北京市中关村医院科研培育专项项目（HX202307） |
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| 中文摘要: |
| 目的：观察体外膈肌起搏器（EDP）联合分阶段康复训练对慢性阻塞性肺病急性加重期（AECOPD）患者的治疗效果。方法：选取我院收治的AECOPD患者94例，随机分为阶段训练组和EDP组各47例。阶段训练组采用分阶段康复训练，EDP组采用分阶段康复训练与EDP联合疗法，均干预2周。干预前后，分别比较2组临床相关指标、血气分析指标、炎症因子水平、生活质量及不良事件情况。结果：EDP组重症监护病房（ICU）入住时间、脱机时间、住院时间均短于阶段训练组（P<0.01）；EDP组氧合指数、动脉氧分压（PaO2）显著高于阶段训练组（P<0.05，0.01）；EDP组血沉（ESR）、二氧化碳分压（PaCO2）、白细胞（WBC）计数、急性生理和慢性健康评分（APACHE Ⅱ）、C反应蛋白（CRP）、血清D-二聚体（D-D）、降钙素原（PCT）水平显著低于阶段训练组（P<0.01）；EDP组不良事件发生率低于阶段训练组（P<0.05）；与治疗前相比，2组的血气分析指标和炎症因子指标均改善（均P<0.01）。结论：AECOPD患者接受EDP+分阶段康复训练联合方案干预，可促进肺功能恢复，具有一定临床应用价值。 |
| 英文摘要: |
| Objective: To explore the effect of extracorporeal diaphragmatic pacing (EDP) combined with staged rehabilitation training on acute exacerbation of chronic obstructive pulmonary disease (AECOPD), as well as its impacts on blood gas indicators and quality of life of patients. Methods: A total of 94 patients with AECOPD admitted to our hospital were selected and divided into the phase training group and the EDP group by the random number table method. The phase training group was given staged rehabilitation training, while the EDP group was subjected to the combined therapy of staged rehabilitation training and EDP. After the intervention ended, clinical related indicators, blood gas analysis indicators, inflammatory factor levels, quality of life, and adverse event situations were compared between two groups. Results: The EDP group had significantly shorter time for ICU stay, weaning, and hospitalization than the phase training group (P<0.01). The EDP group had significantly higher oxygenation index and arterial partial pressure of oxygen (PaO2) than the phase training group (P<0.05,0.01). The levels of erythrocyte sedimentation rate (ESR), PaCO2, white blood cell count (WBC), acute physiology and chronic health evaluation II (APACHE II), C-reactive protein (CRP), serum D-dimer (D-D), and procalcitonin (PCT) in the EDP group were significantly lower than those in the phase training group (P<0.01). The EDP group had a significantly lower incidence of adverse events than the phase training group (P<0.05). Conclusion: The combined intervention of EDP and staged rehabilitation training in AECOPD patients can effectively enhance diaphragm activity and promote lung function recovery, with ideal results and certain clinical value. |
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