| 赵凯旋,丁新浩,白金柱.经颅直流电刺激治疗神经病理性疼痛疗效的Meta分析[J].中国康复,2026,41(1):38-47 |
| 经颅直流电刺激治疗神经病理性疼痛疗效的Meta分析 |
| Efficacy of transcranial direct current stimulation for neuropathic pain: A meta-analysis |
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| DOI：10.3870/zgkf.2026.01.007 |
| 中文关键词: 经颅直流电刺激 神经病理性疼痛 Meta分析 |
| 英文关键词: transcranial direct current stimulation neuropathic pain meta-analysis |
| 基金项目:北京市科技计划项目（Z241100007724002） |
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| 摘要点击次数: 53 |
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| 中文摘要: |
| 目的：应用Meta分析探讨经颅直流电刺激（tDCS）治疗神经病理性疼痛（NP）的干预效果。方法：计算机检索PubMed、Web of Science、Cochrane Library、Embase、知网、万方、维普、中国生物医学文献数据库中关于tDCS治疗NP的随机对照试验（RCT），检索时间自建库开始至2025年3月。使用Cochrane手册评估纳入文献质量、Revman5.4软件对疼痛、抑郁、焦虑结局指标进行Meta分析和GRADE系统对研究结果进行证据等级评价。结果：共纳入19篇文献，共计480名受试者。Meta分析结果显示，tDCS治疗可以显著减轻NP患者的疼痛（SMD=-0.55,95%CI：-0.73~-0.36,P<0.01），经随访，患者1个月后（SMD=-0.42,95%CI：-0.69,-0.15,P<0.01）和3个月后（SMD=-0.59，95%CI；-0.94~-0.23，P<0.01）疼痛缓解，3个月后患者的抑郁（SMD=-0.44，95%CI；-0.66~-0.22，P<0.01）和焦虑（SMD=-0.43，95%CI；-0.69~-0.17，P<0.01）也得到缓解。结论：tDCS可有效减轻NP患者的疼痛，抑郁和焦虑，且安全性好。疼痛性质和刺激部位可能是影响tDCS疗效的重要因素。 |
| 英文摘要: |
| Objective: To investigate the intervention effect of transcranial direct current stimulation (tDCS) in the treatment of neuropathic pain (NP) using meta-analysis. Methods: A computer-based search was conducted in PubMed, Web of Science, Cochrane Library, Embase, CNKI, Wanfang, VIP, and Chinese Biomedical Literature Database for randomized controlled trial (RCT) on tDCS for NP, from the inception of each database to March 2025. The quality of included literatures was evaluated using the Cochrane Handbook, Revman5.4 software was used for meta-analysis of outcome indicators including pain, depression, and anxiety, and the GRADE system was used to rate the level of evidence for research findings. Results: A total of 19 literatures involving 480 subjects were included. Meta-analysis showed that tDCS significantly reduced pain in NP patients (SMD=-0.55, 95%CI:-0.73, -0.36, P<0.01), with sustained effects at 1-month follow-up (SMD=-0.42, 95%CI:-0.69, -0.15, P<0.01) and 3-month follow-up (SMD=-0.59, 95%CI: -0.94, -0.23, P<0.01). Additionally, tDCS alleviated depression (SMD=-0.44, 95%CI: -0.66, -0.22, P<0.01) as well as anxiety (SMD=-0.43, 95%CI: -0.69, -0.17,P<0.01). Conclusion: tDCS effectively reduces pain, depression, and anxiety in NP patients with good safety. The nature of pain and stimulation site may be important factors affecting the efficacy of tDCS. |
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