| 李亚斌,冯海霞,李玲,孙少霞,张娟娟,杨佳丽,李欣楠,曹龙.多靶点磁刺激对脑卒中后肺部感染患者呼吸功能的影响[J].中国康复,2026,41(2):67-72 |
| 多靶点磁刺激对脑卒中后肺部感染患者呼吸功能的影响 |
| Impact of multi-target magnetic stimulation guided by neural circuit modulation on respiratory function in patients with post-stroke pulmonary infection |
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| DOI：10.3870/zgkf.2026.02.001 |
| 中文关键词: 脑卒中 肺部感染 多靶点磁刺激 呼吸功能 神经环路 |
| 英文关键词: stroke pulmonary infection multi-target magnetic stimulation respiratory function neural circuits |
| 基金项目:甘肃省中医药科研课题（GZKP-2023-46）；甘肃省科技计划项目（24JRZA129）；甘肃省卫生健康行业科研项目（GSWSKY2024-26） |
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| 中文摘要: |
| 目的：研究基于神经环路调控的多靶点磁刺激对脑卒中后肺部感染患者呼吸功能的改善效果及神经环路效应。方法：将住院治疗的41例脑卒中后合并肺部感染的患者按随机数字表法分为对照组（20例）和研究组（21例）。2组患者均接受常规肺部感染治疗，研究组在常规治疗基础上给予中枢联合外周多靶点磁刺激治疗。在治疗前、治疗1周和2周后，进行炎症指标（白细胞计数、C反应蛋白）、胸部CT检查、肺功能评估（用力肺活量、第1秒用力呼气容积、步行10m后血氧饱和度测定）、深呼吸任务下膈肌表面肌电图（积分肌电、平均肌电值），治疗前及治疗2周后对研究组进行功能性近红外光谱成像技术(fNIRS)评估。结果：治疗1周及2周后，2组炎症指标均较治疗前逐渐降低（P<0.05），2组胸部CT检查治愈率均逐渐提升（P<0.05），2组肺功能评估、膈肌表面肌电图等评估指标均逐渐升高（P<0.05）。在治疗1周时和2周时的相同时间点上，研究组在肺功能评估、膈肌表面肌电图的评估指标方面显著优于对照组（P<0.05）。治疗2周后，研究组fNIRS评估患者在执行深呼吸任务时上外额叶皮层、额极区、额下回、辅助运动区、前运动皮层、颞中回等脑区对应通道水平的血氧浓度较治疗前显著增高（P<0.05）。结论：基于神经环路调控的多靶点磁刺激可显著改善脑卒中后肺部感染患者的呼吸功能，其恢复过程中伴有特定神经环路的功能重塑。 |
| 英文摘要: |
| Objective: To investigate the improvement of respiratory function and the effect on neural circuits of multi-target magnetic stimulation based on neural circuit regulation in patients with post-stroke pulmonary infection. Methods: A total of 41 inpatients with post-stroke pulmonary infection were randomly divided into a control group (20 cases) and an experimental group (21 cases) using a random number table. Both groups received conventional treatment for pulmonary infection, while the experimental group was additionally given central combined with peripheral multi-target magnetic stimulation on the basis of conventional treatment. Before treatment, and 1 week and 2 weeks after treatment, the following evaluations were conducted in both groups: inflammatory indicators (white blood cell count, C-reactive protein), chest CT examination, pulmonary function assessment (forced vital capacity, forced expiratory volume in the first second, blood oxygen saturation measurement after a 10-meter walk), surface electromyography of the diaphragm during deep breathing tasks (integrated electromyography, average electromyography value), and before and 2 weeks after treatment.functional near-infrared spectroscopy (fNIRS) imaging was conducted in the experiment group. Results: After 1 week and 2 weeks of treatment, the inflammatory markers in both groups were significantly lower than those at baseline and at week 1 (P<0.05). The cure rates of chest CT examinations in both groups were markedly improved compared with baseline and at week 1 (P<0.05). Pulmonary function assessments and diaphragmatic surface electromyography indices in both groups were significantly higher than those at baseline and week 1 (P<0.05). At the same time points (week 1 and week 2), the experimental group exhibited superior performance in pulmonary function assessments and diaphragmatic surface electromyography indices compared with the control group (P<0.05). After 2 weeks of treatment, fNIRS analysis revealed that the experimental group showed significantly increased blood oxygen concentration in brain regions including the superior frontal gyrus, frontal pole, inferior frontal gyrus, supplementary motor area, premotor cortex, and middle temporal gyrus during deep breathing tasks compared with baseline (P<0.05). Conclusion: Multi-target magnetic stimulation based on neural circuit regulation can significantly improve the respiratory function of patients with post-stroke pulmonary infection, and the recovery process is accompanied by functional remodeling of specific neural circuits. |
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