| 刘金明,杨德峰,王博,章志超.正中神经电刺激联合γ节律振荡对获得性脑损伤后意识障碍的影响[J].中国康复,2026,41(2):78-82 |
| 正中神经电刺激联合γ节律振荡对获得性脑损伤后意识障碍的影响 |
| Effect of median nerve electrical stimulation combined with γ-rhythmic oscillation on consciousness disorders after acquired brain injury |
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| DOI：10.3870/zgkf.2026.02.003 |
| 中文关键词: 正中神经电刺激 γ节律振荡 意识障碍 获得性脑损伤 |
| 英文关键词: median nerve electrical stimulation gamma rhythm oscillation consciousness disorders acquired brain injury |
| 基金项目:湖北省卫生健康科技项目(WJ2025M161) |
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| 中文摘要: |
| 目的：探讨正中神经电刺激（MNS）联合40Hz声音刺激所产生的γ节律振荡对获得性脑损伤患者意识状态的影响。方法：采用随机数字表法将获得性脑损伤意识障碍患者72例分成对照组、正中神经电刺激（MNS）组和观察组，每组24例。对照组给予常规康复干预，MNS组在对照组基础上加以正中神经电刺激，观察组在MNS组基础上采用恒定频率为40 Hz、振幅为0.8 Pa的单音进行刺激。于治疗前、治疗4周后采用格拉斯哥昏迷量表（GCS）、昏迷恢复量表（CRS-R）、全面无反应评分量表（FOUR）以及事件相关电位（ERP）对3组患者意识状态情况进行评定。结果：治疗后，3组患者GCS、CRS-R、FOUR评分以及MMN波幅与P300波幅指标较治疗前明显升高，MMN潜伏期较治疗前均明显降低（P＜0.05）；组间比较发现，观察组和MNS组GCS、CRS-R、FOUR评分以及MMN波幅与P300波幅较对照组明显升高，MMN潜伏期较对照组均明显降低（P＜0.05）。结论：正中神经电刺激联合联合40Hz声音刺激所产生的γ节律振荡治疗可显著改善获得性脑损伤患者意识状态，改善患者的意识水平。 |
| 英文摘要: |
| Objective：To explore the impact of median nerve stimulation (MNS) combined with the γ-rhythmic oscillations generated by 40 Hz auditory stimulation on the consciousness state of patients with acquired brain injury. Methods：A total of 72 patients with consciousness disorders following acquired brain injury were divided into a control group, an MNS group, and an observation group using a random number table method, with 24 patients in each group. The control group received conventional rehabilitation intervention, while the MNS group received MNS in addition to the treatment in the control group. The observation group received stimulation with a single tone at a constant frequency of 40 Hz and an amplitude of 0.8 Pa, based on the MNS group's treatment. Before and after 4 weeks of treatment, the Glasgow Coma Scale (GCS), Coma Recovery Scale-Revised (CRS-R), Full Unresponsiveness Outcome Rating Scale (FOUR), and event-related potential (ERP) were used to assess the consciousness state of the patients. Results: After treatment, the GCS, CRS-R, FOUR scores, and MMN amplitude and P300 amplitude indicators in all three groups increased compared to those before treatment, while the MMN latency decreased compared to that before treatment (P<0.05). Intergroup comparisons revealed that the GCS, CRS-R, FOUR scores, and MMN amplitude and P300 amplitude in the observation group and MNS group were higher than those in the control group, and the MMN latency was lower than that in the control group (P<0.05). Furthermore, the above indicators in the observation group were superior to those in the MNS group (P<0.05). Conclusion: The treatment of γ-rhythmic oscillations generated by median nerve electrical stimulation combined with 40 Hz auditory stimulation can significantly improve the consciousness state and level of patients with acquired brain injuries. |
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