| 张丽冉,高茜,刘怡然,夏瑞雪,王馥梅,贾建普.基于前馈控制的运动康复对脑小血管病患者的疗效观察[J].中国康复,2026,41(4):207-211 |
| 基于前馈控制的运动康复对脑小血管病患者的疗效观察 |
| Efficacy of motion rehabilitation based on feedforward control for patients with cerebral small vessel disease |
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| DOI：10.3870/zgkf.2026.04.003 |
| 中文关键词: 前馈控制 运动康复 脑小血管病 肢体运动功能 认知功能 凝血功能 |
| 英文关键词: feedforward control sports rehabilitation cerebral small vessel disease limb motor function cognitive function coagulation function |
| 基金项目:河北省卫生健康委员会医学科学研究课题计划项目（20251551） |
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| 中文摘要: |
| 目的:研究基于前馈控制的运动康复对脑小血管病（CSVD）患者肢体运动功能、认知功能、凝血功能的影响。方法：纳入82例CSVD患者，按随机数字表法分为观察组和对照组各41例。对照组给予胞磷胆碱钠片、阿托伐他汀钙片联合常规运动康复，观察组给予药物治疗联合基于前馈控制的运动康复。治疗前后，评估2组患者肢体运动功能、平衡功能、认知功能，检测血清视锥蛋白样蛋白-1（VILIP-1）、可溶性髓样细胞触发受体2（sTREM2）、血管生成素样蛋白4（ANGPTL4）等认知损伤因子及凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（FIB）等凝血功能指标。结果：治疗前，2组间上述各项比较差异无统计学意义。治疗后，2组简化Fugel-Meyer运动量表（FMA）、Berg平衡量表（BBS）、简易智力状态检查量表（MMSE）、蒙特利尔认知评估量表（MoCA）评分均较治疗前增加（P＜0.01），观察组FMA、BBS、MMSE、MoCA评分均较对照组增加（P＜0.01）。2组血清VILIP-1、sTREM2、FIB均较治疗前降低（P＜0.01），血清ANGPTL4及PT、APTT较治疗前增加（P＜0.01），观察组血清VILIP-1、sTREM2及FIB均低于对照组（P＜0.01），血清ANGPTL4、PT、APTT高于对照组（P＜0.01）。结论：基于前馈控制的运动康复可增强脑小血管病患者肢体运动功能，改善凝血功能、认知损伤因子水平，提高其认知水平。 |
| 英文摘要: |
| Objective: To study the effects of motor rehabilitation based on feedforward control on limb motor function, cognitive function, and coagulation function in patients with cerebral small vessel disease (CSVD). Methods: A total of 82 patients with CSVD were included and divided into the observation group and the control group according to the random number table method, 41 cases in each group. The control group was given cytidine diphosphate choline sodium tablets, atorvastatin calcium tablets, and conventional exercise rehabilitation. The observation group was given drug treatment combined with exercise rehabilitation based on feedforward control. Before and after the treatment, the motor function, balance function and cognitive function of the patients in the two groups were evaluated: the cognitive impairment factors such as serum visinin-like protein-1 (VILIP-1), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), and angiopoietin-like protein 4 (ANGPTL4); coagulation function indicators such as prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen (FIB). Results: Before the treatment, there was no statistically significant difference in any of the above indicators between the two groups. After rehabilitation, the scores of the two groups with the simplified fugel-meyer motor scale (FMA) and the Berg balance scale (BBS) score, mini mental state examination scale score (MMSE) score, Montreal cognitive assessment (MoCA) scores were all higher than those before rehabilitation (P<0.01). After rehabilitation, the FMA score, BBS score, MMSE score and MoCA score in the observation group were all higher than those in the control group (P<0.01). After rehabilitation, the levels of serum VILIP-1, sTREM2 and FIB in both groups were lower than those before rehabilitation, while the levels of serum ANGPTL4, PT and APTT were higher than those before rehabilitation (P<0.01). After rehabilitation, the levels of serum VILIP-1, sTREM2 and FIB in the observation group were lower than those in the control group, while the levels of serum ANGPTL4, PT and APTT in the observation group were higher than those in the control group (P<0.01). Conclusion: Motion rehabilitation based on feedforward control can enhance the limb motor function of patients with CSVD, improve their coagulation function and cognitive impairment factor levels, and increase the cognitive level of patients. |
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