| 李桂兰,李寒,杨泓清.膈肌起搏器联合弹力带训练对稳定期慢性阻塞性肺疾病患者的疗效观察[J].中国康复,2026,41(4):217-221 |
| 膈肌起搏器联合弹力带训练对稳定期慢性阻塞性肺疾病患者的疗效观察 |
| The effects of external diaphragm pacemaker combined with elastic band resistance training on cardiopulmonary function and quality of life in patients with stable chronic obstructive pulmonary disease |
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| DOI：10.3870/zgkf.2026.04.005 |
| 中文关键词: 膈肌起搏器 抗阻训练 慢性阻塞性肺疾病 心肺功能 炎症因子 |
| 英文关键词: diaphragm pacemaker resistance training chronic obstructive pulmonary disease cardiopulmonary function inflammatory factors |
| 基金项目:河北省医学科学研究课题（20241514） |
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| 中文摘要: |
| 目的:探讨稳定期慢性阻塞性肺疾病（COPD）患者经体外膈肌起搏器（EDP）、弹力带抗阻训练（RT）联合训练对其心肺功能、生活质量的影响。方法：选取118例稳定期COPD患者，采用随机数字表法均分为对照组和观察组各59例。对照组行常规药物治疗及EDP治疗，观察组在对照组基础上加用弹力带RT治疗。采用改良版英国医学研究委员会呼吸困难量表（mMRC）、慢阻肺评估测试（CAT）、圣乔治呼吸问卷（SGRQ）评估患者症状、生活质量，比较2组心肺功能［6min步行距离测定（6MWD）、第1秒用力呼气容积占用力肺活量百分比（FEV1/FVC）］、血清炎症因子［基质金属蛋白酶9（MMP-9）、白细胞介素-8（IL-8）］水平、血气分析［动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）］、不良反应。结果：治疗前，2组各项指标比较差异无统计学意义。治疗后，2组mMRC、CAT、SGRQ评分、血清MMP-9、IL-8水平、PaCO2较治疗前均降低（P＜0.01），2组6MWD、FEV1/FVC、PaO2较治疗前均升高（P＜0.01），且观察组各项指标改善显著优于对照组（P＜0.01，0.05）；2组不良反应发生率比较差异无统计学意义。结论：EDP联合RT训练治疗稳定期COPD患者，可以缓解患者症状，减轻炎症反应，提高心肺功能，为临床治疗提供了更多选择方案。 |
| 英文摘要: |
| Objective: To explore the effects of external diaphragm pacemaker (EDP) combined with elastic band resistance training (RT) on cardiopulmonary function and quality of life in patients with stable chronic obstructive pulmonary disease (COPD). Methods: Totally 118 stable COPD patients were randomly assigned into control group (59 cases, receiving conventional treatment combined with EDP) and observation group (59 cases, receiving additional elastic band RT on the basis of control group). The modified version of the Medical Research Council dyspnea scale (mMRC), chronic obstructive pulmonary disease assessment test (CAT), and the St. George's respiratory questionnaire (SGRQ) were used to assess patients' symptoms and evaluate their quality of life. The cardiopulmonary function ［6-minute walking distance (6MWD) measurement, forced expiratory volume in one second (FEV1)/forced vital capacity (FVC)］, serum inflammatory factors ［matrix metalloproteinase-9 (MMP-9), interleukin-8 (IL-8)］, blood gas analysis ［arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2)］ and adverse reaction were compared. Results: Before the treatment, there was no statistically significant difference in the above indicators between the two groups. After treatment, the mMRC, CAT, SGRQ score, serum MMP-9, IL-8, and PaCO2 levels in both groups decreased compared to before treatment (P<0.01). The observation group had lower mMRC, CAT, SGRQ score, serum MMP-9, IL-8, and PaCO2 than the control group (P<0.01). The levels of 6MWD, FEV1/FVC, and PaO2 in both groups increased compared to those before treatment (P<0.01). The observation group had a larger 6MWD, FEV1/FVC, and PaO2 than the control group (P<0.05, 0.01). There was no significant difference in the adverse reactions between the two groups. Conclusion: External diaphragm pacemaker combined with elastic band resistance training can alleviate the degree of respiratory distress and overall condition in patients with stable COPD. It can also reduce lung tissue damage, mitigate systemic inflammatory response, control disease progression, and improve blood gas indicators and cardiopulmonary function, providing more options for clinical treatment. |
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