| Effectiveness of repetitive transcranial magnetic stimulation on negative symptoms of patients with chronic schizophrenia |
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| EN KeyWords: repetitive transcranial magnetic stimulation schizophrenia negative symptom |
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| EN Abstract: |
| Objective: To observe the effect and safety of repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of patients with chronic schizophrenia. Methods: 48 patients with chronic schizophrenia were randomly divided into real rTMS group (study group) and sham rTMS group (control group),with 24 cases in every group. Study group received real rTMS sessions over 4 weeks to the left dorsolateral prefrontal cortex, while the control group received sham rTMS treatment. All patients were given anti-psychotic drug treatment. Both groups were assessed by using Positive and Negative Syndromes Scale (PANSS), and scale for the Assessment of Negative Symptoms (SANS). Results: There were no severe adverse events in the treatment. After 4 weeks of treatment, scores of PANSS and SANS scales in study group were significantly lower than those before treatment and those in control group (P<0.05). Conclusion: Combination of rTMS and antipsychotics is an effective method in treating negative symptoms of patients with chronic schizophrenia. |
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