| The relationship of serum uric acid level with depression and cognitive dysfunction in elderly patients with PD |
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| EN KeyWords: elderly Parkinson disease uric acid depression cognitive |
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| EN Abstract: |
| Objective: To investigate the change of serum uric acid level and its relationship with depression and cognitive dysfunction in old patients with Parkinson disease(PD). Methods: Serum uric acid was measured in 55 elderly PD patients (PD group)and 55 healthy elderly people (control group). Elderly PD patients were measured by Hamilton depression rating scale( HAMD) and Mini-mental state examination scale( MMSE). Results:The level of serum uric acid of PD group was significantly lower than that of control group(P＜0.05),and the level of serum uric acid of PD patients with depression or cognitive dysfunction was significantly lower than that in PD patients without depression or cognitive dysfunction (all P＜0.05).The MMSE score in PD group with depression was significantly lower than that in PD patients without depression(P＜0.05).Conclusions:The level of serum uric acid in elderly PD patients is decreased significantly,which even lower in elderly PD patients with depression or cognitive dysfunction. |
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