| Effects and mechanism of functional training combined with nicergoline on stroke patients with asymptomatic dysphagia |
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| EN KeyWords: nicergoline stroke asymptomatic dysphagia substance P |
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| EN Abstract: |
| Objective:To investigate the clinical effect and mechanism of nicergoline in the treatment of stroke patients with symptomless dysphagia.Methods:Sixty cases of stroke patients with symptomless dysphagia through a simple two-step swallowing provocation test (STS-SPT) were randomly divided into the observation group and control group with 30 cases in each group.Both groups were given the basic swallowing function and eating training,and the observation group was given nicergoline (15 mg,tid) additionally.The STS-SPT was repeated 4 weeks after the start of treatment. Before and 12 weeks after the treatment,serum concentration of substance P (SP) was measured by using radioimmunoassay.Results:Four weeks after treatment,the remission rate of stroke patients with asymptomatic dysphagia in observation group was significantly higher than in control group (P<0.01).The two groups were divided into subgroup A1，B1 and A2，B2 depending on swallowing function better or not through STS-SPT test.Twelve weeks after treatment,the level of serum SP in observation group was significantly increased as compared with pretreatment and in control group after treatment(all P<0.01).Patients in subgroup A1 and B1 showed significantly increased serum levels of SP,and more significantly in subgroup A1 than in subgroup B1(P<0.01,0.05).Conclusion:Nicergoline can significantly improve asymptomatic dysphagia in stroke patients probably by increasing serum levels of SP. |
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