| Objective:To observe the effectiveness of oral pregabalin combined with transcutaneous electric nerve stimulation in the treatment of postherpetic neuralgia.Methods:Fifty-two cases of postherpetic neuralgia were randomly divided into control group and observation group.Both groups were given oral pregabalin 300 mg,twice daily for 4 weeks,and observation group was given transcutaneous electric nerve stimulation in the pain spot additionally.Visual analogue scale (VAS) and sleep quality score (QS) were used to assess the effects,and adverse reactions were observed.Results:After treatment for 1,2,3,4 weeks,VAS and QS scores were significantly decreased in both groups as compared with pretreatment(all P<0.05),more significantly in observation group than in control group(all P<0.05).The adverse effects between the two groups had no significant difference.Conclusion:Pregabalin plus transcutaneous electric nerve stimulation can effectively relieve postherpetic neuralgia and improve sleep quality,with no obvious adverse effects. |
