| Objective:To investigate the effects of injection of citicoline into Zusanli point on neural dysfunction of rats following traumatic brain injury.Methods:Forty healthy adult male Sprague-Dawley (SD) rats were randomly divided into five groups:sham operated group (A),acupuncture point drug injection group (B),acupuncture point saline injection group (C),intraperitoneal drug injection group (D) and control group (E).Opened brain trauma was induced by the improved Feeney method in the 32 rats of groups B,C,D and E.Eight sham-operated rats were subjected to the same surgical procedure,except brain injury.The rats in groups B and C were treated with acupuncture injection of citicoline or saline daily respectively.The rats in groups D and E were treated with intraperitonea injection of citicoline or saline daily respectively.The treatment continued for 14 days.On the 1st,2nd,4th,6th,8th,10th,12th and 14th day after injury,the alteration of neural function in rats was assessed by using neurological severity score,balance test and slanting board test.Results:The neurological severity score and the balance test score in groups B,C,D and E were increased significantly as compared with those before injury and in group A on the 1st day after injury (P<0.05),then gradually decreased.The scores in group B were lower than in groups C,D and E except the 1st day after injury (P<0.05).The inclined board angle in groups B,C,D and E was decreased markedly as compared with that before injury and in group A (P<0.05).The inclined board angle in group B was more than that in groups C,D and E from the 2nd day after injury (P<0.05).Conclusion:Acupuncture point drug injection therapy could significantly promote the recovery of neural dysfunction after traumatic brain injury. |
