| Effects of exogenous creatine phosphate on glutamic acid and Ca2+ -ATPase activity in brain of mice after exhaustive exercise |
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| DOI： |
| EN KeyWords: exhaustive exercise creatine phosphate glutamic acid Ca2+ -ATPase |
| Fund Project:大连医科大学大学生科技创新活动基金资助项目（2013022） |
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| EN Abstract: |
| Objective:To observe the effects of exogenous creatine phosphate on glutamic acid level and Ca2+ -ATPase activity in brain of mice after exhaustive exercise and to further reveal the mechanism of exogenous creatine phosphate in allaying tiredness.Methods:All 36 mice,6-week-age,were divided into 4 groups:exhaustive swimming control group (group A);exhaustive swimming with medication group (group B);8-min swimming control group (group C);and 8-min swimming with medication group (group D).The method of mice weight-loading swimming was used to sets up the model of exhaustive exercise,and each mouse loaded weight with 6% of the mass of itself.Thirty min before the experiment,mice in groups B and D were given the intraperitoneal injection with creatine phosphate sodium by the standard of 1000 mg/kg,and the mice in groups A and C were given the same proportionate normal saline as placebo.The exhaustive swimming time was recorded,and glutamic level and Ca2+ -ATPase activity were measured by using biochemical kits.Results:After testing,the exhaustion time in group B was longer than that in group A (P<0.05).The Glu contents in groups B and D were significantly lower than in groups A and C (P<0.05).Ca2+ -ATPase activity in groups B and group D was significantly higher than that in groups A and C (P<0.05).Conclusion:The mechanism of exogenous creatine phosphate in allaying tiredness may be closely related with increased Ca2+ -ATPase activity and reduced glutamic level. |
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