| Effects of rehabilitation pretreatment on IL-23/IL-17 axis of mice with experimental autoimmune encephalomyelitis |
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| DOI： |
| EN KeyWords: experimental autoimmune encephalomyelitis rehabilitation pretreatment IL-23/IL-17 axis |
| Fund Project:黑龙江省2012年研究生创新科研资金项目（YJSCX2012-346HLJ） |
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| EN Abstract: |
| Objective:To explore the effects of rehabilitation pretreatment (RT) on interleukin-23 (IL-23)/IL-17 axis of mice with experimental autoimmune encephalomyelitis (EAE).Methods:After C57BL/6 mice were subjected to rehabilitation pretreatment (treadmill training),EAE model was induced in mice,and EAE group and RT-EAE group were established.Normal mice were selected as control group.The mean neurobehavioral scores were measure,and the serum levels of IL-23 and IL-17 were detected by using ELISA.Results:The mean neurobehavioral scores in RT-EAE group were significantly lower than in EAE group (1.44±0.56 vs. 2.75±1.13,P<0.05).The expression of IL-23 and IL-17 in EAE group was significantly higher than in control group and RT-EAE group (P<0.05).Conclusion:RT can delay the occurrence of EAE probably by inhibiting the IL-23/IL-17 axis. |
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