| Therapeutic effect of repetitive transcranial magnetic stimulation for bipolar depressive disorder |
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| DOI： |
| EN KeyWords: repetitive transcranial magnetic stimulation bipolar depressive disorder effect stimulation parameters |
| Fund Project:湖州市科技计划项目（2010YSB01） |
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| EN Abstract: |
| Objective:To assess the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) in the treatment of bipolar depressive disorder.Methods:All 71 patients with bipolar depressive disorder were randomly assigned to lamotrigine treatment in combination with rTMS (study group) or sham procedure (control group) on left dorsal-lateral prefrontal cortex.Results:After treatment of two weeks,the Hamilton depression scale-17 items (HAMD) and the clinical global impression-severity of illness (CGI-SI) total scores of both groups were significantly improved (P<0.01),but there was no significant difference between the two groups.After treatment of four weeks,the HAMD and CGI-SI total scores of both groups were significantly improved as compared with those before treatment and after treatment of two weeks,and more obviously in study group than in control group (all P<0.01).The response rate was significantly greater in study group than in control group after treatment (63.89% vs.25.71%,P<0.01).Conclusion:Augmentative rTMS was effective and well tolerated in bipolar depressive patients.It suggests that rTMS can be used as a good choice in the treatment of bipolar depressive disorder. |
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