| Effects of electroacupuncture at jiaji (EX-B2) on the expression of biglycan in rabbit degenerated intervertebral disc |
| |
| DOI： |
| EN KeyWords: electroacupuncture jiaji(EX-B2) intervertebral disc degeneration biglycan |
| Fund Project:1.2011年国家自然科学基金面上项目（81173324）；2.2010年湖北省自然科学基金项目（2010CD034）；3.2010年湖北省卫生厅年度科研项目［鄂卫函（2010）820号］ |
|
| View Counts: 12020 |
| PDF Download Counts: 8564 |
| EN Abstract: |
| Objective:To study the action mechanism of the EA at jiaji points against lumbar disc degeneration.Methods:Thirty-six New Zealand white rabbits were randomly divided into 4 groups:normal group,sham operation group,model group and treatment group.The disc degenernation model was established by using the external dynamic compression device attached to the rabbit lumbar spine for 28 days.Treatment group was given the EA at jiajia point.For each group,the discs were examined radiographically,and double-labelling immunofluorescence was used to detect the expression of biglycan before operation,28th,and 56th day after operation.Result:At 28th day after operation,the expression of biglycan in model group and treatment group was significantly declined as compared with sham operation group(P<0.01 for all).At 56th day after operation,the expression of biglycan in treatment group was significantly increased compared to that at the 28th day after operation in model group and treatment group(P<0.05 for all).Conclusion:EA at jiaji(EX-B2) could protect the degenerated intervertebral discs through up-regulating the expression of biglycan,and correcting the imbalance between extracellular matrix synthesis and degradation. |
|
查看全文
Download PDF Reader HTML Full Text |
| Close |
|
|
|
