| Objective:To study the effect of electroacupuncture (EA) at BL40 on CK,VEGF and MVD in rabbits with psoas muscle damage,and discuss the possible mechanism of EA at BL40 repairing the psoas muscle damage from the perspective of angiogenesis.Methods:Thirty-two male rabbits were randomly divided into the EA at BL40 group (BL40 group),EA at Ouch point (OP) group (OP group),model group and blank group.In model group,BL40 group and OP group,the rabbit psoas muscle damage model was established by psoas muscle contusion.thereafter,the BL40 group and OP group were given electroacupuncture treatment.Two weeks later,CK,VEGF and MVD contents were detected.Results:Two weeks after modeling,the serum CK and the expression of VEGF and MVD in the psoas muscle in the model group were significantly increased as compared with the blank group (P<0.01).The serum CK and the expression of MVD in the psoas muscle in the BL40 and OP groups were statistically increased (P<0.01,0.05),but the expression of VEGF in psoas muscle had no significant change in comaprison to the blank group. As compared with the model group,the serum CK and the expression of VEGF and MVD in the psoas muscle in the BL40 and OP groups were significantly decreased (P<0.01).There was no statistically significant difference between the BL40 group and OP group.Conclusion:Two weeks after psoas muscle injury in rabbits,EA at BL40 can reduce serum CK levels and promote repair of the psoas muscle damage,probably by down-regulating the expression of VEGF to advance its role in angiogenesis,and reducing capillary regeneration time to cut down the expression of MVD. |
