| Objective:To investigate the relationship between functional features of multimode MR scan and cognitive impairment in patients with cerebral small vessel disease.Methods:Fifteen cases of cerebral small vessel diseases and 15 healthy subjects were recruited as observation group and control group,respectively.The cognitive impairment was evaluated using the mini-mental state examination (MMSE),Montreal cognitive assessment (MoCA),and National Institute of Health Stroke Scale (NIHSS).The average diffusion coefficient (ADC),fractional anisotropy(FA) and cerebral micro bleeding were assessed using multimode MR scan.The relationship between small cerebral vessel disease and cognitive decline was also analyzed.Results:The MMSE and MoCA scores were obviously lower, and NIHSS score was higher in observation group than in control group (P<0.01 for all). The FA value in frontal temporal lobe, parietal lobe and basal ganglia was obviously lower,the ADC value and number of cerebral microbleeding were significantly higher in observation group than in control group (P<0.05 for all). The number of cerebral microbleedings, the FA value and ADC value in frontal temporal lobe had a close relationship with the cognitive impairment (P<0.05). Conclusion: The number of cerebral microbleedings and the severity of white matter damage were strongly associated with the cognitive decline. |
