| Effects of botulinum toxin A injection in combination with functional training on standing and walking in children with spastic cerebral palsy |
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| DOI： |
| EN KeyWords: botulinum toxin A lower extremity spasticity cerebral palsy |
| Fund Project:广州市卫生局资助项目（20131A011067）；（201102A213019） |
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| EN Abstract: |
| Objective:To study the effects of botulinum toxin A (BTX-A) injection in combination with functional training on standing and walking in children with spastic cerebral palsy (SCP). Methods: One hundred children with SCP were randomly divided into a BTX-A group and a control group (n=50 each). The children in the BTX-A group were treated with BTX-A injected into spastic muscles in the lower extremity combined with functional training, and those in the control group with functional training alone. Composite to Spasticity Scale (CSS) scores and Gross Motor Function Measure (GMFM) DE scores were recorded before and at 2nd week, and 3rd month and 6th month after treatment. Results: After treatment for 2 weeks, 3 months and 6 months, CSS scores in the lower extremity were significantly reduced as compared with those before treatment, and those at 3rd and 6th month after treatment were significantly lower than in the control group (P<0.05). The GMFM (DE) scores after treatment were significantly increased in both two groups as compared with those before treatment, and those at 3rd and 6th month after treatment were significantly higher than in the control group (P<0.05). Conclusion: BTX-A injection or functional training can release spastic muscles in the lower extremity, and improve their activity ability. BTX-A injection in combination with functional training is more effective on reducing spasticity and improving functional standing and walking in children with SCP. |
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