| Effect of ultra-early hyperbaric oxygen therapy on brain water content and infarction volume after focal cerebral ischemia in rats |
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| EN KeyWords: rats cerebral ischemia ultra-early hyperbaric oxygen infarction volume brain water content |
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| EN Abstract: |
| Objective: To investigate the effect of ultra-early hyperbaric oxygen therapy on focal cerebral ischemia of rats. Method: The thread-occluded method was used to make middle cerebral artery occlusion (MCAO) model. Sixty Sprague-Dawly rats were randomly divided into 3 groups: sham operated group, ischemic control group and hyperbaric oxygen therapy group. The rats were killed 12 h after ischemia. The percentage of infarction (infarct ratio) was calculated by dividing the infarct volume by total volume of the slices. Result: As compared with ischemic control group, the percentage of infarction and brain water content were significantly reduced in hyperbaric oxygen therapy group (P<0.05). Conclusion: Ultra-early hyperbaric oxygen therapy can treat cerebral ischemia effectively via reducing infarction volume and brain water content. |
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