| Objective: To investigate the effectiveness of rehabilitation training combined with atorvastatin in the treatment of subcortical ischemic vascular dementia (SIVD) on cognitive function and activities of daily living. Methods: A total of 56 patients with SIVD were enrolled consecutively and randomly divided into 2 groups: rehabilitation training combined with atorvastatin group (observation group) and donepezil group (control group). Mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA) and Barthel index (BI) were assessed and compared between the two groups before treatment, and at first and 6th month after treatment. Results: The cognitive function and behavioral abilities were similar in the two groups at the end of the first month. However, the MMSE, MoCA and Barthel indexes were significantly higher at the 6th month than those before treatment and at the first month in the two groups (P<0.05), and they were even higher in the observation group than in the control group (P<0.01). A higher effective rate was found in the observed group than that in the control group (P<0.05). Conclusion: Rehabilitation training combined with atorvastatin showed an obvious long-term effectiveness on the cognitive function and activities of daily living recovery in patients with SIVD, and its effectiveness is superior to donepezil. |
