| Protective effects of electroacupuncture on Baihui on permanent middle cerebral artery occlusion |
| |
| DOI： |
| EN KeyWords: electroacupuncture mice cerebral infarction BK-channel |
| Fund Project:国家自然基金（81371222） |
|
| View Counts: 11345 |
| PDF Download Counts: 7799 |
| EN Abstract: |
| Objective: To study the protective effect of electroacupuncture (EA) on Baihui on mice model of permanent occlusion of middle cerebral artery (MCAO). Methods: The MCAO model of mice were established and subjected to cerebral infarction by intraluminal occlusion of the middle cerebral artery. After intervention for 4 weeks, the lesion volume, the neurological impairment scores and the expression of Bcl-xl were observed and compared between the EA group and acupuncture group (psydoacupuncture). Patch clamp method was used in the the surrounding area of the infarction, and the change of BK-channel was observed. Result: The lesion volume and the neurological impairment scores in EA group were significantly reduced as compare with those in acupuncture group (P<0.01). The expression of Bcl-xl was higher in EA group than in acupuncture group (P<0.01). Patch clamp results showed that the BK-channel function of the neurons in EA group was significantly better than in acupuncture group in the surrounding area of the infarction (P<0.01). Conclusion: EA on Baihui can reduce the lesion volume and improve neurological function probably by up-regulating the expression of Bcl-xl and also by improving the function of neurons BK-channel. |
|
查看全文
Download PDF Reader HTML Full Text |
| Close |
