| Effect of repetitive transcranial magnetic stimulation on cognitive function in patients with Alzheimer disease |
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| DOI： |
| EN KeyWords: repetitive transcranial magnetic stimulation Alzheimer disease cognitive function |
| Fund Project:湖北省教育厅优秀中青年人才项目（Q20101316） |
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| EN Abstract: |
| Objective: To study the effect of repetitive transcranial magnetic stimulation (rTMS) on the learning and memory function in patients with Alzheimer disease (AD). Methods: Sixty patients with AD were randomly and equally assigned to rTMS group and control group (n=30 each). The patients in control group were treated with piracetam for 16 weeks, and those in rTMS group were treated with 20Hz rTMS. Before and after treatment, the primary efficacy was evaluated by using the Mini-Mental Status Examination (MMSE), the Alzheimer Disease Assessment Scale cognition (ADAS-cog) and Montreal Cognitive Assessment (MoCA). Results: The scores of MoCA and MMSE scale in rTMS group were significantly higher than before treatment and the control group (P<0.05). The scores of ADAS-cog scale in rTMS group were obviously lower than before treatment and the control group (P<0.05). There was significant difference in the scores of MoCA and MMSE scale and the scores of ADAS-cog scale before and after treatment in the control group. Conclusions: rTMS treatment can improve memory and cognitive functions in patients with AD. |
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