| Objective: To compare the effects of botulinum toxin A (BTX-A) injection plus physiotherapy, or physiotherapy alone on the food pressure in children with spastic cerebral palsy (SCP). Methods: 213 children with SCP were randomly divided into two groups: BTX-A group (BTX-A injections combined with physical therapy, 108 cases) and control group (physical therapy, 105 cases). Two groups received 2 weeks of hospital-based physiotherapy, and 10 weeks of home-based physiotherapy. Outcome assessments included foot pressure measured by GHW type plantar pressure tester, modified Ashworth scale (MAS), D and E dimensions of the Gross Motor Function Measure (GMFM), and physician rating scale was determined before and 2, 12 weeks after treatment. Results: Children in BTX-A group showed an improvement of foot pressure, spasticity, standing and walking, gait 2 and 12 weeks after treatment as compared with those before treatment (P<0.05). These scores in control group were improved at 12th week only. Furthermore, there was significant difference in foot pressure, spasticity, standing and walking, gait between two groups at 12th week (P<0.05). Conclusion: BTX-A injection combined with physical therapy was advantageous in improving foot pressure, spasticity, walking, and gait in children with SCP. |
