| Objective: To observe the influence of the early rehabilitation treatment on neural function and cytokines in patients with depression after stroke. Methods: 110 patients with depression after stroke were randomly divided into rehabilitation group and the control group, 55 cases in each group. The two groups were treated with routine treatment in the Department of Neurology. Moreover, the rehabilitation group received early rehabilitation treatment. Before and after treatment, the degree of depression was assessed by Hamilton Depression Rating Scale (HAMD), the motor function was assessed by Fug-meyer score (FMA), and the ability of daily life was assessed by Modified Barthel Index (MBI). The levels of serum interleukin-1 (IL-1), IL-6 and tumor necrosis factor (TNF-α) were analyzed using radioimmunoassay. Results: Four weeks after treatment, HAMD score and the score of each factor of two groups were significantly lower than those before treatment (P<0.05), and the score of rehabilitation group was significantly lower than that of control group (P<0.05). The FMA and MBI scores were significantly increased in two groups after treatment (P<0.05), and those in rehabilitation group were significantly higher than in the control group (P<0.05). The levels of serum IL-1, IL-6 and TNF-α in two groups were significantly lower after treatment than those before treatment (P<0.05), and those in rehabilitation group were significantly lower than in the control group (P<0.05). Conclusion: Early rehabilitation therapy can significantly improve the depression after stroke, which may be achieved by lowering the level of serum cytokines. |
