| Objective: To observe the effect of repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training on cognitive function in patients with mild cognitive impairment (MCI). Methods: Eighty patients with MCI were randomly divided into 2 groups, 40 cases in each group. The observation group was treated with rTMS therapy combined with cognitive training, and the control group was treated with cognitive training alone. The patients in the two groups were assessed by the Montreal cognitive assessment scale (MoCA) and event related potential (ERP) P300 test before and after treatment. Results: After 8-week treatment, MOCA factor score and total scores of observation group were significantly higher than those before treatment and those of the control group (P<0.05, or 0.01). In control group, the scores of visual space, executive, delay memory, language, attention, calculation, orientation and total scores were significantly higher than those before treatment (P<0.05), and the scores of naming and abstract ability had no statistically significant difference before and after treatment .The latencies of P300 in two groups were significantly shorter than those before treatment (P<0.05), and those were significantly shorter in the observation group than in the control group (P<0.05). The amplitudes of the two groups were significantly higher than those before treatment (P<0.05), and the increased degree of the amplitudes in observation group was significantly higher (P<0.05). Conclusion: rTMS combined with cognitive function training has obvious effect on cognitive function of patients with MCI, and is superior to cognitive function training used alone. |
