| Objective:To explore the effect of repetitive transcranial magnetic stimulation (rTMS) combined with donepezil in treating patients with mild or moderate Alzheimer's disease(AD) and its safety. Methods：Five-two patients with mild or moderate AD were randomly divided into the study group (26 cases) and the control group (26 cases). Patients in control group received donepezil treatment alone and those in study group underwent high-rTMS combined with donepezil treatment. The Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), Mini-mental State Examination(MMSE) and Activities of Daily Living (ADL) were performed before and 4 weeks, 8 weeks, 12 weeks after treatment. Event-related potentials (ERP) P300 was performed before and 12 weeks after treatment. Results：As compared with the condition before treatment, the study group at 8th week, 12th week after treatment, the control group at 8th week after treatment, the scores of both ADAS-Cog and ADL were declined significantly, while the MMSE were increased significantly. At 12th week after treatment, P300 latency period of the two groups was reduced significantly, and the amplitude increased significantly. The evaluation indexes in study group were improved better than those in control group. Conclusion：rTMS assisted donepezil could effectively improve the patient's cognitive function and daily living skills, and delay the process of brain function. The combination of rTMS with donepezil is superior to the single use of donepezil with a high safety. |
