| Effects of rTMS on recovery of memory function and interleukin-1 in hippocampus after focal cerebral ischemia |
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| DOI： |
| EN KeyWords: transcranial magnetic stimulation cerebral ischemia spatial memory interleukin-1 |
| Fund Project:广东省自然科学基金博士启动项目(S2013040013489) |
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| EN Abstract: |
| Objective: To investigate the effects of rTMS in high frequency on the recovery of spatial memory function and the expression of interleukin-1beta (IL-1β) mRNA in ipsilesional hippocampus of rats subjected to focal cerebral ischemia. Methods: A rat model of acute focal cerebral ischemia was established using transient middle cerebral artery occlusion technique. Forty-five rats were randomly assigned to sham operative group, ischemic control group and rTMS group. Spatial memory function was evaluated by Morris water maze. The expression of pro-inflammatory cytokines (IL-1β, iNOS, TNF-α) in ipsilesional hippocampus and ischemic core was detected by real-time quantitative polymerase chain reaction. Results: The escape latency in ischemic control group and rTMS group was delayed more than that in sham operative group (P<0.01). The escape latency in rTMS group was significantly shortened as compared with that in model control group (P<0.05). The expression of IL-1β, iNOS and TNFα mRNA was increased in ischemic group and rTMS group (P<0.01) as compared with sham operative group (P<0.01). In the hippocampus, the expression of IL-1β mRNA in rTMS group was significantly increased as compared with that in the ischemic control group (P<0.01). In the ipsilateral cortex, there was no significant difference in the expression of IL-1β mRNA between rTMS group and ischemic control group. Conclusion: rTMS can promote the recovery of spatial memory function, which was possibly achieved by increasing the expression of IL-1β mRNA in the ipsilateral hippocampus. |
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