| Long-term efficacy of high-frequency repetitive transcranial magnetic stimulation for treating negative symptoms of chronic schizophrenia |
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| DOI： |
| EN KeyWords: repetitive transcranial magnetic stimulation schizophrenia negative symptoms |
| Fund Project:无锡市医院管理中心医学科研项目（YGZXQ1307），南京医科大学科技发展面上基金项目（2013NJMU206） |
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| EN Abstract: |
| Objective: To investigate the long-term efficacy and safety of high-frequency repetitive transcranial magnetic stimulation (rTMS) for treating the negative symptoms of chronic schizophrenia. Methods: Sixty cases of chronic schizophrenia were randomly assigned to 10 Hz rTMS group (the study group), and sham rTMS group (the control group). In the study group, patients were stimulated with 10 Hz rTMS in the left dorsolateral prefrontal cortex, 5 times every week for 2 weeks. The Positive and Negative Syndrome Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS) were used to assess the improvement of negative symptoms before and 2 weeks after rTMS, and during a follow-up period of 14 weeks. Results: Two weeks after rTMS and during a follow-up period of 14 weeks, the total and the negative symptoms scores of the PANSS and the scores of SANS in the study group were significantly decreased after the treatment (P<0.01) and significantly less than those in the control group (P<0.01). However, the study group had no notable change in positive symptoms and general factors scores of PANSS among different time points. In the control group, the total and each symptom scores of the PANSS and the scores of SANS had no obvious change. Conclusion:10 Hz rTMS has a long-term effectively and safety therapeutic potential on the negative symptoms of chronic schizophrenia. |
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