| Effects of repetitive transcranial magnetic stimulation on spasticity in patients with incomplete spinal cord injury |
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| DOI： |
| EN KeyWords: spinal cord injury spasticity rTMS F wave H reflex Hmax/Mmax |
| Fund Project:国家自然科学基金青年项目（81101458） |
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| EN Abstract: |
| Objective: To observe the effects of high frequency repetitive transcranial magnetic stimulation (rTMS) on spasticity in patients with incomplete spinal cord injury (SCI). Methods: Eighteen patients with incomplete SCI received 4 weeks of daily sessions of active (n=18) rTMS on the leg motor area (10 Hz and an intensity of 90% of resting motor threshold). Seven healthy persons served as control group. All patients were assessed by the Modified Ashworth Scale (MAS) before and after rTMS treatment. In this study, we evaluated the effect of high frequency rTMS on the lower extremity spasticity and motor neuron excitability by comparing the difference in the mean latency of F wave (F-lat) and H reflex (H-lat), the ratio of the maximum amplitude of H reflex and the maximum amplitude of M wave (Hmax/Mmax) of the patients before and after the rTMS treatment. Results: A significant improvement in lower limb spasticity which was assessed by the score of MAS was observed in patients after rTMS treatment (P<0.05). The F-lat-mean, H-lat-mean and Hmax/Mmax were significantly increased in the SCI group as compared with those in the control group (P<0.05). A significant decrease of Flat-mean was measured following active rTMS while H reflex and H/M did not change. There was no correlation before or after rTMS treatment between H/M and MAS respectively. Conclusion: High-frequency rTMS can improve spasticity in patients with incomplete SCI, and it can be assessed by several electrophysiological parameters such as F wave and H-reflex. It is suggested that high frequency rTMS can be used as a possible useful treatment for incomplete SCI patients, and it is also worth to be studied further. |
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