| Objective: To investigate the incidence of post-stroke depression (PSD) and its risk factors one month after stroke. Methods: 160 stroke inpatients were enrolled and divided into the PSD group and the non-PSD group according to the scores of HAMD. Demographics, clinical features and blood biochemistry tests (e.g. total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, fasting glucose, C-reactive protein, homocysteine, etc.) were collected in each patient. The National Institute of Health stroke scale (NIHSS) was assessed at admission and one month after stroke. The Barthel index of ADL (BI) and Fugl-Meyer Motor Function Assessment (FMA) were assessed at 1st month after stroke. All parameters were compared and analyzed, and the difference between PSD group and non-PSD group was calculated. Further, multivariable logistic regression was used to assess the independent risk factors. Results: The incidence of PSD during the recovery period was 38.1%. The incidence of mild, moderate and severe PSD was 12.5%, 16.9% and 8.7% respectively. The scores of NIHSS both at admission and one month after stroke were higher (P<0.05), and the scores of BI and FMA were lower one month after stroke (P<0.05) in the PSD group than in the non-PSD group. The PSD group had worse hand function and walking ability one month after stroke, and had more complex regional pain syndrome one month after stroke (P<0.05). Logistic regression analysis revealed that the levels of homocysteine and C-reactive protein, NIHSS scores at admission, the number of ischemic lesions, complex regional pain syndrome and walking ability were the relevant factors of PSD during the recovery period. Conclusions: The levels of homocysteine and C-reactive protein, NIHSS scores at admission, the number of ischemic lesions, complex regional pain syndrome and walking ability were the risk factors of PSD during the recovery period. |
